7144-13-0

Basic information

• Product Name: 1-(2-chloroethyl)-3-phenylurea
• Synonyms: urea, N-(2-chloroethyl)-N'-phenyl-
• CAS NO: 7144-13-0
• Molecular Formula: C₉H₁₁ClN₂O
• Molecular Weight: 198.6494
• Mol File: 7144-13-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 297.4°C at 760 mmHg
• Flash Point: 133.7°C
• Density: 1.247g/cm³
• Vapor Pressure: 0.00135mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 1-(2-chloroethyl)-3-phenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroethyl)-3-phenylurea(7144-13-0)
• EPA Substance Registry System: 1-(2-chloroethyl)-3-phenylurea(7144-13-0)

Safety Data

• Hazardous Substances Data: 7144-13-0(Hazardous Substances Data)

Usage

General Description

1-(2-chloroethyl)-3-phenylurea, also known as chlorotoluron, is a chemical compound used as an herbicide to control grasses and broad-leaved weeds. It works by inhibiting the photosynthetic electron transport in plants, ultimately leading to their death. Chlorotoluron is commonly applied to crops such as cereals, potatoes, and sugar beets, as well as on non-crop land. Exposure to chlorotoluron can be harmful, as it is considered a potential endocrine disruptor and is toxic to aquatic organisms. Additionally, it has been found to persist in the environment and can contaminate water sources. Therefore, proper precautions and safety measures should be taken when using or handling this chemical.

Upstream product

• 13279-22-6 1-(phenylaminocarbonyl)aziridine 
• 20729-41-3 acetaldehyde imine 
• 103-71-9 phenyl isocyanate 
• 1943-83-5 2-chloroethyl isothiocyanate 
• 62-53-3 aniline 

Downstream Products

• 27151-01-5 4,5-dihydro-N-phenyl-2-oxazolamine 
• 1848-69-7 1-phenylimidazolidin-2-one 
• 27151-01-5 2-(phenylimino)oxazolidine 
• 959780-53-1 N-4-[125I]iodophenyl-N'-2-chloroethylurea 
• 146257-20-7 4-iodo-[3-(2-chloroethyl)ureido]benzene 
• 20485-98-7 1-ethyl-3-phenyl-2-imidazolidinone 
• 1422528-00-4 3,4-dimethoxyphenyl 4-(3-butyl-2-oxoimidazolidin-1-yl)benzenesulfonate 
• 1422528-02-6 3,4-difluorophenyl 4-(3-butyl-2-oxoimidazolidin-1-yl)benzenesulfonate 
• 1422527-83-0 3,5-dimethoxyphenyl 4-(3-butyl-2-oxoimidazolidin-1-yl)benzenesulfonate 
• 1422528-03-7 3,5-difluorophenyl 4-(3-butyl-2-oxoimidazolidin-1-yl)benzenesulfonate 
• 1422528-05-9 3,5-dichlorophenyl 4-(3-butyl-2-oxoimidazolidin-1-yl)benzenesulfonate 
• 1422528-10-6 3,5-dibromophenyl 4-(3-butyl-2-oxoimidazolidin-1-yl)benzenesulfonate 
• 1422527-82-9 3,4,5-trimethoxyphenyl 4-(3-butyl-2-oxoimidazolidin-1-yl)benzenesulfonate 
• 1328953-99-6 4-(2-oxo-3-propylimidazolidin-1-yl)benzene-1-sulfonyl chloride 

Relevant articles and documents

Hydroamination and Hydrophosphination of Isocyanates/Isothiocyanates under Catalyst-Free Conditions

Symmetrical and unsymmetrical N,N’-disubstituted as well as trisubstituted ureas/thioureas by the hydroamination of isocyanates/isothiocyanates, and various phosphathioureas by the hydrophosphination of isothiocyanates have been synthesized in good to excellent yields under catalyst-free and mild conditions. This protocol is also applicable for the efficient synthesis of chiral ureas and thioureas and common herbicides, such as fenuron and monuron.

4-(3-Alkyl-2-oxoimidazolidin-1-yl)-N-phenylbenzenesulfonamides as new antimitotic prodrugs activated by cytochrome P450 1A1 in breast cancer cells

The role and the importance of the sulfonate moiety in phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates (PAIB-SOs) were assessed using its bioisosteric sulfonamide equivalent leading to new cytochrome P450 1A1 (CYP1A1)-activated prodrugs designa

SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS

Compounds of formula (I): wherein R1, R2, R3, R4, R7, R6, R7, R8, R9, A, X and Y as defined herein are provided as useful for the treatment of cancer or for