7145-00-8

Usage

Properties

Organic compound, containing an amino group, a bromine atom, and a carboxylic acid functional group

Uses

Commonly used in organic synthesis and chemical research

Applications

Building block in the preparation of various pharmaceuticals and biologically active molecules, suitable for use in peptide synthesis and as a precursor in the production of amino acids

Reactivity

The bromine atom adds reactivity to the compound, making it useful as a starting material for various chemical transformations

Upstream product

• 50428-03-0 D,L-propargylglycine 
• 6326-44-9 diethyl 2-formylaminomalonate 
• 513-31-5 2-bromoallyl bromide 
• 134038-94-1 diethyl 2-(2-bromoprop-2-en-1-yl)-2-acetamidopropanedioate 

Relevant academic research and scientific papers

A non-natural amino acid N - tert-butoxycarbonyl - L - 2 - amino - 4 - bromo - 4 - pentenoic acid preparation method (by machine translation)

The invention relates to a non-natural amino acid N - tert-butoxycarbonyl - L - 2 - amino - 4 - bromo - 4 - preparation of pentenoic acid method, mainly solves the original synthetic method step more, cycle is long, and high cost. The technical scheme of the present invention is: the 2, 3 - dibromo propylene and acetyl malonic acid alkali pulls out the hydrogen layer which the system results in the bromine propylene acetyl amino-malonic acid diethyl ester intermediate. [...] malonic acid diethyl ester intermediate is saponified, split, on uncle butoxycarbonyl protecting group gets the N - tert-butoxycarbonyl - L - 2 - amino - 4 - bromo - 4 - pentenoic acid. Non-natural amino acid N - tert butoxycarbonyl - L - 2 - amino - 4 - bromo - 4 - pentenoic acid and intermediate is an important raw material in the field of polypeptide synthesis. (by machine translation)