7145-43-9 Usage
Uses
Used in Metal Ion Detection:
Trifluoroacetaldehyde thiosemicarbazone is used as a chelating agent for metal ion detection due to its ability to form stable complexes with metal ions, which aids in their identification and quantification.
Used in Enzyme Inhibition:
TAT is utilized as an enzyme inhibitor, leveraging its chelating properties to bind with metal ions in enzymes, thereby inhibiting their activity and offering potential therapeutic benefits.
Used in Anti-Cancer Therapy:
In the field of oncology, trifluoroacetaldehyde thiosemicarbazone is used as an anti-cancer agent, where its metal-chelating properties can disrupt essential metal-dependent processes in cancer cells, leading to their inhibition or death.
Used in Chemical Research:
TAT is employed as a research tool in chemical studies, where its unique reactivity and stability contribute to the understanding of metal ion interactions and the development of new chemical processes or compounds.
Used in Pharmaceutical Development:
In the pharmaceutical industry, trifluoroacetaldehyde thiosemicarbazone is used as a starting material or intermediate in the synthesis of drugs that target metal-dependent pathways, potentially leading to the creation of novel therapeutics for various diseases, including cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 7145-43-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,1,4 and 5 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 7145-43:
(6*7)+(5*1)+(4*4)+(3*5)+(2*4)+(1*3)=89
89 % 10 = 9
So 7145-43-9 is a valid CAS Registry Number.
7145-43-9Relevant academic research and scientific papers
Synthesis, biological evaluation and molecular modeling study of thiadiazolo[3,2-a][1,3]diazepine analogues of HIE-124 as a new class of short acting hypnotics
El-Subbagh, Hussein I.,Hassan, Ghada S.,El-Taher, Kamal E.H.,El-Messery, Shahenda M.,El-Azab, Adel S.,Abdelaziz, Alaa A.-M.,Hefnawy, Mohamed M.
, p. 237 - 247 (2016/09/09)
A new series of 6,7-dihydro-[1,3,4]thiadiazolo[3,2-a][1,3]diazepine analogues were synthesized, and biological evaluated. Compound GS-62 (33) exhibited potent in?vivo short acting hypnotic activity with onset time, duration of sleep and therapeutic index of 6.4?±?0.2, 94.8?±?5.3?min, 6.62, respectively), in comparison to thiopental sodium (6). Compounds 33 did not show any sign of acute tolerance reported with the maintenance dose of 6. Meanwhile 33 potentiated the in?vivo hypnotic effect of 6 in an equimolar amounts (0.06?mmol) combination showing an onset and duration of 7.5?±?1.3, 62.5?±?5.9?min, respectively. This combination allowed the use of lower doses of both drugs to avoid the undesirable side effects. Docking studies revealed favorable interactions and binding to BDZ binding site of the GABAAreceptor especially with Arg87, Arg149, and Thr151 amino acid residues.
