7145-43-9

Basic information

• Product Name: trifluoroacetaldehyde thiosemicarbazone
• CAS NO: 7145-43-9
• Molecular Formula: C₃H₄F₃N₃S
• Molecular Weight: 171.1442
• Mol File: 7145-43-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 148.2°C at 760 mmHg
• Flash Point: 43.4°C
• Density: 1.56g/cm³
• Vapor Pressure: 4.27mmHg at 25°C
• Refractive Index: 1.492
• CAS DataBase Reference: trifluoroacetaldehyde thiosemicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: trifluoroacetaldehyde thiosemicarbazone(7145-43-9)
• EPA Substance Registry System: trifluoroacetaldehyde thiosemicarbazone(7145-43-9)

Safety Data

• Hazardous Substances Data: 7145-43-9(Hazardous Substances Data)

Usage

General Description

Trifluoroacetaldehyde thiosemicarbazone, also known as TAT, is a chemical compound that is commonly used as a chelating agent in various fields of chemistry and biology. It is a derivative of thiosemicarbazone, a class of compounds known for their ability to complex with metal ions. TAT has a trifluoromethyl group attached to the acetaldehyde moiety, which imparts unique properties to the compound, such as increased stability and reactivity. This makes TAT particularly useful in applications such as metal ion detection, enzyme inhibition, and anti-cancer therapy. Overall, trifluoroacetaldehyde thiosemicarbazone is a versatile and valuable chemical with potential for diverse applications in research and industry.

Upstream product

• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 79-19-6 thiosemicarbazide 

Relevant articles and documents

Synthesis, biological evaluation and molecular modeling study of thiadiazolo[3,2-a][1,3]diazepine analogues of HIE-124 as a new class of short acting hypnotics

A new series of 6,7-dihydro-[1,3,4]thiadiazolo[3,2-a][1,3]diazepine analogues were synthesized, and biological evaluated. Compound GS-62 (33) exhibited potent in?vivo short acting hypnotic activity with onset time, duration of sleep and therapeutic index of 6.4?±?0.2, 94.8?±?5.3?min, 6.62, respectively), in comparison to thiopental sodium (6). Compounds 33 did not show any sign of acute tolerance reported with the maintenance dose of 6. Meanwhile 33 potentiated the in?vivo hypnotic effect of 6 in an equimolar amounts (0.06?mmol) combination showing an onset and duration of 7.5?±?1.3, 62.5?±?5.9?min, respectively. This combination allowed the use of lower doses of both drugs to avoid the undesirable side effects. Docking studies revealed favorable interactions and binding to BDZ binding site of the GABAAreceptor especially with Arg87, Arg149, and Thr151 amino acid residues.