71458-44-1Relevant academic research and scientific papers
Highly potent and selective cannabinoid receptor 2 agonists: Initial hit optimization of an adamantyl hit series identified from high-through-put screening
Nettekoven, Matthias,Fingerle, Jürgen,Grether, Uwe,Grüner, Sabine,Kimbara, Atsushi,Püllmann, Bernd,Rogers-Evans, Mark,R?ver, Stephan,Schuler, Franz,Schulz-Gasch, Tanja,Ullmer, Christoph
, p. 1177 - 1181 (2013/03/14)
A series of highly potent & selective adamantane derived CB2 agonists was identified in a high-throughput screen. A SAR was established and physicochemical properties were significantly improved. This was accompanied by potency of the compounds on the Q63R variant and varying β-arrestin data which will support the insight into their relevance for the in vivo situation.
Complexes of silicon and phosphorus chlorides with nitrogen-containing bases as the condensing agents in the synthesis of amides
Besgubenko, L. V.,Pipko, S. E.,Sinitsa, A. D.
, p. 1382 - 1390,9 (2020/09/16)
High effectiveness of new condensing agents on the basis of complexes of silicon and phosphorus chlorides with nitrogen-containing bases in the synthesis of amides from carboxylic acids and amines and also in heterocyclization is shown. Factors affecting the readiness of formation of the amide bond and the yields of the final products are established.
