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N-(2-hydroxyphenyl)-N-[(4-methylphenyl)sulphonyl]acetamide, commonly known as Mafenide, is a sulfonamide medication characterized by its white to off-white crystalline powder form. It is recognized for its ability to penetrate bacterial cell walls and inhibit the synthesis of dihydropteroate, a precursor to folic acid, thereby disrupting the production of essential biomolecules like DNA, RNA, and proteins. This action leads to the death of the microorganism. Additionally, Mafenide exhibits anti-inflammatory properties, making it a valuable component in the treatment of burn injuries.

71463-41-7

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71463-41-7 Usage

Uses

Used in Burn Wound Treatment:
N-(2-hydroxyphenyl)-N-[(4-methylphenyl)sulphonyl]acetamide is used as a topical treatment for burn wounds to prevent and treat bacterial or fungal infections. Its mechanism of action involves the inhibition of dihydropteroate synthesis, which is crucial for the production of folic acid, thereby disrupting the microorganism's ability to produce DNA, RNA, and proteins, leading to its death.
Used in Anti-Inflammatory Applications:
In the context of burn injuries, N-(2-hydroxyphenyl)-N-[(4-methylphenyl)sulphonyl]acetamide is used for its anti-inflammatory properties to help reduce pain and inflammation associated with the affected area.
Used in Pharmaceutical Industry:
N-(2-hydroxyphenyl)-N-[(4-methylphenyl)sulphonyl]acetamide is used as an active pharmaceutical ingredient in the formulation of creams or solutions for direct application to burn wounds, providing both antimicrobial and anti-inflammatory benefits.
Common side effects of using N-(2-hydroxyphenyl)-N-[(4-methylphenyl)sulphonyl]acetamide include pain, burning, and itching at the application site, with the possibility of allergic reactions in some individuals.

Check Digit Verification of cas no

The CAS Registry Mumber 71463-41-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,4,6 and 3 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 71463-41:
(7*7)+(6*1)+(5*4)+(4*6)+(3*3)+(2*4)+(1*1)=117
117 % 10 = 7
So 71463-41-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H15NO4S/c1-11-7-9-13(10-8-11)21(19,20)16(12(2)17)14-5-3-4-6-15(14)18/h3-10,18H,1-2H3

71463-41-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(2-hydroxyphenyl)-N-(4-methylphenyl)sulfonylacetamide

1.2 Other means of identification

Product number -
Other names Acetamide,N-(2-hydroxyphenyl)-N-[(4-methylphenyl)sulfonyl]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:71463-41-7 SDS

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