7147-44-6

Basic information

• Product Name: 1-(2-chlorophenyl)-N-hydroxyethanimine
• CAS NO: 7147-44-6
• Molecular Formula: C₈H₈ClNO
• Molecular Weight: 169.6082
• Mol File: 7147-44-6.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 284.6°C at 760 mmHg
• Flash Point: 125.9°C
• Density: 1.18g/cm³
• Vapor Pressure: 0.00139mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: 1-(2-chlorophenyl)-N-hydroxyethanimine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chlorophenyl)-N-hydroxyethanimine(7147-44-6)
• EPA Substance Registry System: 1-(2-chlorophenyl)-N-hydroxyethanimine(7147-44-6)

Safety Data

• Hazardous Substances Data: 7147-44-6(Hazardous Substances Data)

Usage

General Description

1-(2-chlorophenyl)-N-hydroxyethanimine is a chemical compound with the molecular formula C8H8ClNO. It is a known organic intermediate used in the synthesis of pharmaceutical drugs and agrochemicals. 1-(2-chlorophenyl)-N-hydroxyethanimine is also used in the production of dyes, pigments, and other organic chemicals. It is a white to off-white solid with a melting point of 98-101 °C. It is important to handle this compound with care as it may cause irritation to the skin, eyes, and respiratory system upon contact or inhalation.

Upstream product

• 609-65-4 o-chlorobenzoyl chloride 
• 89-98-5 2-chloro-benzaldehyde 
• 2039-87-4 2-chlorostyrene 
• 2142-68-9 1-(2-chlorophenyl)ethanone 

Downstream Products

• 109261-07-6 1-(2-chloro-phenyl)-ethanone-((E)-O-picryl oxime ) 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 349537-53-7 1-acetylamino-1-(2'-chlorophenyl)ethene 
• 896905-07-0 1-(2-chlorophenyl)ethanone O-acetyl oxime 
• 1207166-25-3 N-(1-(2-chlorophenyl)ethyl)-P,P-diphenylphosphinic amide 

Relevant articles and documents

Rhodium(iii)-catalyzed asymmetric [4+1] spiroannulations of: O -pivaloyl oximes with α-diazo compounds

Chiral RhIII catalysts can catalyze the asymmetric [4+1] spiroannulation of O-pivaloyl oximes with α-diazo homophthalimides under redox-neutral and acid/base-neutral conditions, leading to formation of chiral spirocyclic imines as a result of C-H activation and N-O cleavage. The reaction proceeded with high efficiency and features broad substrate scope, mild reaction conditions, and high to excellent enantioselectivities. This journal is

Direct Enamido C(sp2)?H Diphosphorylation Enabled by a PCET-Triggered Double Radical Relay: Access to gem-Bisphosphonates

Herein we report a novel and straightforward protocol for the construction of valuable gem-BPs by means of proton-coupled electron-transfer (PCET)-triggered enamido C(sp2)?H diphosphorylation. This reaction represents a rare example of realizing the challenging double C?P bond formation at a single carbon atom, thus providing facile access to a broad variety of structurally diverse bisphosphonates from simple enamides under silver-mediated conditions. Initial mechanistic studies demonstrated that the diphosphorylation involves two rounds of PCET-initiated radical relay process.

Copper(0)/PPh3-Mediated Bisheteroannulations of o-Nitroalkynes with Methylketoximes Accessing Pyrazo-Fused Pseudoindoxyls

A copper(0)/PPh3-mediated cascade bisheteroannulation reaction of o-nitroalkynes with methylketoximes has been developed that provides viable access to a diverse range of pyrazo-fused pseudoindoxyl compounds. Synthetically useful functional groups including sensitive C-I bonds are compatible with this system. Mechanistic studies suggest a reaction cascade involving sequential PPh3-mediated deoxygenative cycloisomerization and copper-catalyzed [3 + 2] pyrazo-annulation.