71483-05-1Relevant academic research and scientific papers
COMPOUNDS AS RAS INHIBITORS AND USE THEREOF
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Paragraph 0195, (2019/04/11)
A compound of Formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same and method of using the same are also described.
Synthesis of phenylthiomethyl substituted furans by Lewis acid catalysed substitution
Greeves,Torode
, p. 1109 - 1112 (2007/10/02)
Two routes to the differentially functionalised trisubstituted furan methyl 4-methyl-2-[(phenylthio)methyl]-3-furoate are presented. One is a direct palladium catalysed annulation which proceeds smoothly in the presence of a thioether and the other depends on a highly chemoselective displacement of a methoxy group by phenylthiotrimethylsilane. The scope and mechanism of the latter transformation was probed with simple model systems.
Calcium channel blocking and positive inotropic activities of ethyl 5-cyano-1,4-dihydro-6-methyl-2-[(phenylsulfonyl)methyl]-4-aryl-3-pyrid ine-carboxylate and analogues. Synthesis and structure-activity relationships
Sircar,Gregor,Anderson,Haleen,Shih,Weishaar,Steffen,Pugsley,Taylor
, p. 2248 - 2260 (2007/10/02)
The synthesis and pharmacological evaluation of a series of 2-[(arylsulfonyl)methyl]-4-aryl-5-cyano-1,4-dihydropyridine-3-carboxyl ic acid esters and analogues are described. These compounds possess a unique profile namely, calcium channel blocking and positive inotropic activities in vitro. Compound 54 was selected as the best compound in the series and was studied in detail. The synthesis and biological profiles of enantiomers of 54 are also reported. The data indicate that although the calcium channel blocking property of 54 is stereospecific the positive inotropic activity is not. Examples of 3- and 6-cyano and other closely related 1,4-dihydropyridine derivatives are described and evaluated for comparison and were found to be devoid of dual activities mentioned above.
HETEROADAMANTANES AND THEIR DERIVATIVES. 3. THE SYNTHESIS OF 6-HYDROXY-5-METHOXYCARBONYL-1,3-DIAZAADAMANTANE
Kuznetsov, A. I.,Boiko, I. P.,Sokolova, E. B.,Basargin, E. B.,Unkovskii, B. V.
, p. 557 - 559 (2007/10/02)
The interaction of methyl 3-oxo-4-(phenylthio)butyrate with formaldehyde and ammonium acetate yielded 5-methoxycarbonyl-6-oxo-7-phenylthio-1,3-diazaadamantane, which, on being heated with skeletal nickel in isopropanol was converted into 6-hydroxy-5-metho
