714960-96-0Relevant academic research and scientific papers
Synthesis and in vitro inhibitory activity on human platelet aggregation of novel properly substituted 4-(1-piperazinyl)coumarins
Di Braccio, Mario,Grossi, Giancarlo,Roma, Giorgio,Signorello, Maria Grazia,Leoncini, Giuliana
, p. 397 - 409 (2007/10/03)
Pursuing our chemical and biological studies in this field, we described the multistep preparation of the new 5-, 6-, or 7-alkoxy and 7-alkoxy-8-methyl substituted 4-(1-piperazinyl)coumarins 5d-v, as well as the in vitro evaluation of their inhibitory activity on human platelet aggregation induced in platelet-rich plasma by ADP, collagen or the Ca2+ ionophore A23187. Compounds 5h-j,p,r-u showed notably high activity towards all the platelet aggregation inducers used, and the most active one, 8-methyl-4-(1-piperazinyl)- 7-(3-pyridylmethoxy)coumarin (5t), proved to be a potent in vitro antiplatelet agent.
