714965-77-2

Upstream product

• 98-58-8 4-bromobenzenesulfonyl chloride 
• 13351-61-6 2,2-dimethyl-3-phenyl-1-propanol 
• 5720-05-8 4-methylphenylboronic acid 
• 693782-23-9 2,2-dimethyl-3-phenyl-1-propyl 4-bromobenzenesulfonate 

Downstream Products

• 613-33-2 (4,4'-dimethyl-1,1'-biphenyl) 

Relevant academic research and scientific papers

Nickel-catalyzed cross-coupling of neopentyl arenesulfonates with methyl and primary alkylmagnesium bromides

(Chemical Equation Presented) Neopentyl arenesulfonates were reacted with methyl and primary alkylmagnesium bromides in the presence of dp-peNiCl 2, via the nucleophilic aromatic substitution of neopentyloxysulfonyl groups by the primary alkyl nucleophiles, to produce the corresponding alkylarenes in good yields. This result shows that the alkyloxysulfonyl group might be a suitable alternative to halides and triflate in some circumstances.

Preparation of unsymmetrical terphenyls via the nickel-catalyzed cross-coupling of alkyl biphenylsulfonates with aryl Grignard reagents

Unsymmetrical terphenyl derivatives were prepared by sequential transition metal-catalyzed cross-coupling reactions of neopentyl bromobenzenesulfonates with arylboronic acids and arylmagnesium bromides in good yields. Biphenylsulfonates undergo nickel-catalyzed coupling reactions more rapidly than the corresponding benzenesulfonates. The stepwise palladium- and nickel-catalyzed reaction of the bromobenzenesulfonates appears to be a promising and conceptually straightforward route for preparing unsymmetrical terphenyls.