714966-72-0Relevant articles and documents
A new total synthesis of (±)-oestrone
Pattenden, Gerald,Reddy, L. Krishnakanth,Walter, Affo
, p. 4027 - 4030 (2004)
A conceptually new total synthesis of oestrone, based on a novel cascade of radical cyclisations from the iodo aryl vinylcyclopropane 2, via 10, 15, 16 and 17, leading to the intermediate trans,anti,trans-oestradiol derivative 11 in one step, is described. Oxidation of 11, followed by demethylation of the resulting aryl methyl ether 18 then gives (±)-oestrone 1.