714974-23-9

Upstream product

• 335060-49-6 (2S,4R)-5-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2,4-dimethylpentyl acetate 
• 157837-64-4 (2R,4S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2,4-dimethylpentan-1-ol 
• 147782-80-7 (2S,4R)-5-(tert-butyl(dimethyl)silyloxy)-2,4-dimethyl-1-pentanol 
• 90270-02-3 (2R,4S)-1-hydroxy-2,4-dimethylpentyl acetate 
• 79-22-1 methyl chloroformate 
• 157837-65-5 (2R,4S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2,4-dimethylpentanal 
• 570394-37-5 (S)-1-(((4,4-dibromo-2-methylbut-3-en-1-yl)oxy)methyl)-4-methoxybenzene 

Downstream Products

• 714974-18-2 (1''S,1'''R,2'''R,3S,4S,6S,8R,10S)-3-(tert-butyldimethyl-silyloxy)-4,6,8,10-tetramethyl-11-(tetrahydropyran-2'-yloxy)undecanoic acid 6''-bromo-6''-cyano-1-[2'''-(4'''-methoxymenzyloxymethyl)cyclopentyl]hexa-3''E,5''E-dienyl ester 
• 714974-20-6 (1'R,2S,2'R,8R,9S,11R,13S,15S,16S)-9,16-bis(tert-butyldimethylsilyloxy)-2-[2'-(4''-methoxybenzyloxymethyl)cyclopentyl]-9,11,13,15-tetramethyl-18-oxo-oxaoctadeca-4E,6Z-diene-7-carbonitrile 
• 714974-19-3 (1'S,1''R,2''R,3S,4S,6S,8R,10S)-3-(tert-butyldimethylsilyloxy)-11-hydroxy-4,6,8,10-tetramethylundecanoic acid 6''-bromo-6''-cyano-1-[2'''-(4'''-methoxymenzyloxymethyl)cyclopentyl]hexa-3''E,5''E-dienyl ester 
• 714974-07-9 (2S,4E,6Z,8R,9S,11R,13S,15S,16S)-16-(tert-butyldimethylsilyloxy)-8-hydroxy-2-{(1R,2R)-2-[(4-methoxybenzyloxy)methyl]cyclopentyl}-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-diene-7-carbonitrile 
• 714974-06-8 (2S,4E,6Z,8S,9S,11R,13S,15S,16S)-16-(tert-butyldimethylsilyloxy)-8-hydroxy-2-{(1R,2R)-2-[(4-methoxybenzyloxy)methyl]cyclopentyl}-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-diene-7-carbonitrile 
• 714973-93-0 (1'S,1''R,2''R,3S,4S,6S,8R,10S)-3-(tert-butyldimethylsilyloxy)-4,6,8,10-tetramethyl-11-oxoundecanoic acid 6''-bromo-6''-cyano-1-[2'''-(4'''-methoxymenzyloxymethyl)cyclopentyl]hexa-3''E,5''E-dienyl ester 
• 714974-10-4 (3'S,4R,4'S,6'S,8'R,10'S)-4-benzyl-3-[3'-hydroxy-4',6',8',10'-tetramethyl-11'-(tetrahydropyran-2''-yloxy)undecanoyl]-2-oxazolidinone 
• 714974-12-6 (2S,4S,6R,8S)-1-(tert-butyldiphenylsilyloxy)-2,4,6,8-tetramethyl-9-(tetrahydropyran-2'-yloxy)nonane 
• 714973-97-4 (-)-(2S,4R,6S,8S)-9-(tert-butyl-diphenyl-silyloxy)-2,4,6,8-tetramethyl-nonan-1-ol 
• 714973-95-2 (2S,6R,8S)-9-(tert-butyldiphenylsilyloxy)-2,6,8-trimethylnon-3-yn-1-ol 
• 7184-60-3 borrelidin 
• 714974-08-0 (2S,6R,8S)-9-(tert-butyldiphenylsilyloxy)-1-(4'-methoxybenzyloxy)-2,6,8-trimethylnon-3-yne 

Relevant academic research and scientific papers

Total synthesis of (-)-borrelidin

Matrix presented. The total synthesis of borrelidin has been achieved. The best feature of our synthetic route is Sml2-mediated intramolecular Reformatsky-type reaction for macrocyclization after esterification between two segments. The two key segments were synthesized through chelation-controlled carbotitanation, chelation-controlled hydrogenation, stereoselective Reformatsky reaction, and MgBr2·Et2O-mediated chelation-controlled allylation.