715-14-0Relevant academic research and scientific papers
Styrene sulfone NLRP3 inflammasome inhibitor, preparation method and application thereof
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Paragraph 0053; 0078-0081; 0084-0085, (2020/10/30)
The invention relates to the field of styrene sulfone compounds and NLRP3 inhibitors, and particularly provides a styrene sulfone NLRP3 inflammasome inhibitor, a preparation method and application thereof, wherein the inhibitor is represented by a formula (1), n is selected from 0 and 1, X is selected from N and O, R1 is selected from different electron withdrawing or electron donating substituents, and R2 is selected from different fat or aromatic substituents. According to the invention, it is verified that the compounds represented by the general formula have NLRP3 inhibitory activity.
Pharmaceutical compositions containing acrylic acid derivatives and their use in the medicine
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, (2008/06/13)
Known acrylic acid derivatives of formula wherein, n is an integer of from 0 to 2,R represents a hydrogen, an alkaline or an alkaline earth metal atom, or a C1 4alkyl-group, and, R1 represents a hydrogen or a halogen atom or a C
Novel acrylic acid salts, a process for their preparation, pharmaceutical compositions containing them and their use in the medicine
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, (2008/06/13)
Novel acrylic acid salts of formula STR1 wherein R represents a hydrogen or a halogen atom, a C1-4 alkyl, a C1-4 alkoxy or a nitro group, M represents a cation derived from bismuth, zinc or a pharmaceutically acceptable organic base,
Novel acrylic acid salts, a process for their preparation, pharmaceutical compositions containing them and their use in the medicine
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, (2008/06/13)
Novel acrilic acid salts of formula wherein, R represents a hydrogen or a halogen atom, a C1 4alkyl,a C1 4alkoxy or a nitro group,M represents a cation derived from bismuth, zinc or a pharmaceutically acceptable
