715-60-6

Usage

Uses

Used in Pharmaceutical Industry:
1-PENTAFLUOROPHENYL-2-THIOUREA is used as a building block for the synthesis of new drugs due to its capacity to form hydrogen bonds, which is crucial for the development of pharmaceutical compounds with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 1-PENTAFLUOROPHENYL-2-THIOUREA is utilized as a precursor in the production of various agrochemicals, potentially enhancing crop protection and yield through targeted pest and disease control.
Used in Catalysis:
1-PENTAFLUOROPHENYL-2-THIOUREA is employed as a catalyst or catalyst precursor in cross-coupling reactions, a significant process in organic chemistry that facilitates the formation of carbon-carbon bonds, contributing to the synthesis of complex organic molecules.
Further research into the properties and applications of 1-PENTAFLUOROPHENYL-2-THIOUREA is ongoing, indicating its potential for future expansion into additional fields and industries.

InChI:InChI=1/C7H3F5N2S/c8-1-2(9)4(11)6(14-7(13)15)5(12)3(1)10/h(H3,13,14,15)

Upstream product

• 771-60-8 2,3,4,5,6-pentafluoroaniline 

Downstream Products

• 70015-95-1 4,5,6,7-tetrafluorobenzo[d]thiazol-2-amine 

Relevant academic research and scientific papers

Disrupting the Conserved Salt Bridge in the Trimerization of Influenza A Nucleoprotein

Antiviral drug resistance in influenza infections has been a major threat to public health. To develop a broad-spectrum inhibitor of influenza to combat the problem of drug resistance, we previously identified the highly conserved E339?R416 salt bridge of the nucleoprotein trimer as a target and compound 1 as an inhibitor disrupting the salt bridge with an EC50 = 2.7 μM against influenza A (A/WSN/1933). We have further modified this compound via a structure-based approach and performed antiviral activity screening to identify compounds 29 and 30 with EC50 values of 110 and 120 nM, respectively, and without measurable host cell cytotoxicity. Compared to the clinically used neuraminidase inhibitors, these two compounds showed better activity profiles against drug-resistant influenza A strains, as well as influenza B, and improved survival of influenza-infected mice.

Benzo[4,5]thiazolo[3,2-c][1,3,5,2]oxadiazaborinines: Synthesis, Structural, and Photophysical Properties

A family of highly emissive benzo[4,5]thiazolo[3,2-c][1,3,5,2]oxadiazaborinines, conjugated with the donor 4-dimethylaminophenyl group, was designed and synthesized. Their photophysical, both in solution and in the solid state, and structural properties were investigated. The influence of donor and acceptor substituents (R) in the benzothiazole unit on photophysical properties of complexes was found out. The tetrafluorobenzothiazole analogue exhibits nonbonded nuclear spin-spin coupling between fluorines from the BF2 group and α-fluorine atom at the benzene ring. Additionally, this boron complex demonstrates a comparatively high solid-state fluorescence quantum yield (φ = 0.34).