7150-74-5 Usage
General Description
GAMMA-METHYLENE-DL-GLUTAMIC ACID, also known as Gabaculine, is a synthetic inhibitor of gamma-aminobutyric acid (GABA) transaminase. It is a structural analogue of the neurotransmitter GABA and functions by irreversibly inhibiting the enzyme responsible for GABA catabolism, leading to increased levels of GABA in the brain. This, in turn, results in a sedative effect and has potential applications in the treatment of epilepsy and other neurological disorders. However, its use is limited due to its non-specific inhibitory effects and potential for toxicity. Overall, GAMMA-METHYLENE-DL-GLUTAMIC ACID has shown promise as a research tool and in the study of GABAergic neurotransmission.
Check Digit Verification of cas no
The CAS Registry Mumber 7150-74-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,1,5 and 0 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 7150-74:
(6*7)+(5*1)+(4*5)+(3*0)+(2*7)+(1*4)=85
85 % 10 = 5
So 7150-74-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H9NO4/c1-3(5(8)9)2-4(7)6(10)11/h4H,1-2,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
7150-74-5Relevant academic research and scientific papers
Synthesis of two cyclic analogs of glutamic acid: cis- and trans-pyrrolidine-2,4-dicarboxylic acids
Trigalo, Franois,Molliex, Christophe,Champion, Brigitte,Azerad, Robert
, p. 3049 - 3050 (2007/10/19)
The tosyl ester 2 of tetraethyl 1-acetamido-4-hydroxybutane- 1,1,3,3-tetracarboxylate gave 4-methylene glutammic acid in 90% yield by refluxing with concentrated HC1. Treatment of 2 with NaOEt, then with refluxing concentrated HC1 gave a 54% yield of cis
Reactions of a Glycidyl Radical Equivalent with 2-Functionalised Allyl Stannates
Baldwin, Jack S.,Adlington, Robert M.,Lowe, Christopher,O'Neil, Ian A.,Sanders, Gillian L.,et al.
, p. 1030 - 1031 (2007/10/02)
Reaction of 2-bromo-N-benzoylglycine methyl ester with 2-functionalised allyl stannane reagents under radical conditions provides a new route to α-alkylated amino acids in good yield, as exemplified by the facile synthesis of 4-methylene glutamate.
