71502-43-7

Usage

Uses

Used in Pharmaceutical Industry:
5-Isoxazolemethanol, α,3-dimethylis utilized as a key building block in the synthesis of pharmaceutical compounds. Its unique structure and biological activity make it a valuable component in the development of new drugs, potentially contributing to the creation of innovative treatments and therapies.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Isoxazolemethanol, α,3-dimethylserves as a crucial intermediate in the synthesis of various agrochemicals. Its incorporation can lead to the development of novel pesticides or other agricultural products that enhance crop protection and yield.
Used in Organic Chemistry Research and Development:
5-Isoxazolemethanol, α,3-dimethylis employed as a research compound in the field of organic chemistry. It is used to explore new synthetic pathways, investigate its reactivity, and understand its role in complex chemical reactions, thereby advancing the knowledge and capabilities of organic chemistry.

InChI:InChI=1/C6H9NO2/c1-4-3-6(5(2)8)9-7-4/h3,5,8H,1-2H3

Upstream product

• 14400-67-0 2,5-dimethyl-2,3-dihydrofuran-3-one 
• 55086-61-8 5-acetyl-3-methylisoxazole 
• 5780-37-0 (E)-acetaldoxime 
• 2028-63-9 but-3-yn-2-ol 
• 79-24-3 Nitroethane 
• 683-58-9 acetohydroximoyl chloride 
• 107-29-9 Acetaldehyde oxime 

Downstream Products

• 55086-61-8 5-acetyl-3-methylisoxazole 
• 138958-51-7 4-[2-[2,3-Dihydro-2-(4-fluorophenyl)-2-methyl-3-oxo-5-furanyl]ethenyl]benzonitrile 
• 138958-52-8 2-methyl-2-(4-fluorophenyl)-5-[2-(2-pyridinyl)ethenyl]-3(2H)-furanone 
• 138958-53-9 (E)-2-(4-fluorophenyl)-2-methyl-5-[2-(thien-3-yl)ethenyl]-3(2H)-furanone 
• 138958-50-6 4-[(E)-2-(5-Methyl-4-oxo-5-phenyl-4,5-dihydro-furan-2-yl)-vinyl]-benzonitrile 
• 138958-46-0 2-methyl-2-phenyl-5-[2-(2-pyridinyl)ethenyl]-3(2H)-furanone 
• 138958-48-2 2-Methyl-2-phenyl-5-((E)-2-pyridin-4-yl-vinyl)-furan-3-one 
• 138958-47-1 2-phenyl-2-methyl-5-[2-(3-pyridinyl)ethenyl]-3(2H)-furanone 
• 138958-49-3 (E)-2-methyl-2-phenyl-5-[2-(thien-3-yl)ethenyl]-3(2H)-furanone 
• 138958-57-3 1-(4-fluorophenyl)-1-(3-methyl-5-isoxazolyl)-1-ethanol 
• 138958-56-2 1-(3-methyl-5-isoxazolyl)-1-phenyl-1-ethanol 
• 133255-54-6 2-methyl-2-(4-fluorophenyl)-5-methyl-3(2H)-furanone 
• 133255-53-5 2,5-dimethyl-2-phenyl-3(2H)-furanone 
• 104777-32-4 2-bromo-1-(3-methyl-1,2-oxazol-5-yl)ethanone 

Relevant academic research and scientific papers

ALKYNYL ALCOHOLS AS KINASE INHIBITORS

Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like.

COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF

The present invention provides novel beta-secretase inhibitors of the general formula (I), where the variables A1, A2, L1, L2, L3, R1, R2, R3, R4, R5, R6 and R7 are as defined in the claims, a method for their use in treating Alzheimer's disease, and methods for their use in reducing memapsin 2 catalytic activity.

New 5-(2-ethenylsubstituted)-3(2H)-furanones with in vitro antiproliferative activity

A convenient route to new 3(2H)-furanones is described through hydrogenolysis and subsequent acidic hydrolysis of isoxazoles. The antiproliferative activity of title compounds were evaluated against leukemia-, carcinoma-, neuroblastoma-, and sarcoma-derived human cell lines in comparison to the natural compound geiparvarin. The structure activity relationship indicated that the maximum in vitro antiproliferative activity correlates with the presence of a heterocyclic ring on the ethenyl moiety.

Synthesis and pharmacological characterization of new analogs of broxaterol

A series of isoxazole derivatives structurally related to broxaterol 1 has been prepared and tested for their potency to β1 and β2 adrenergic receptors. At variance with broxaterol, none of the tested compounds displayed agonistic activity. The 3-isopropenyl derivative 5f is the most potent antagonist both in the trachea and atria preparations.

Synthesis and antiulcer activity of novel 5-(2-ethenyl substituted)-3(2H)- furanones

In order to investigate new antiulcer agents, spizofurone 1 (AG-629) was fragmented and reassembled to generate 5-phenyl-2,2-dimethyl-3(2H)-furanone (bullatenone, 2). Because of the antiulcer activity of 2,5-phenyl-substituted 2,2-dimethyl-3(2H)-furanones (3-6) were made and shown to have poor activity. Insertion of an ethenyl link between the furanone and phenyl rings gave 5-(2- phenylethenyl)-2,2-dimethyl-3(2H)-furanone (7). This compound had better activity than 2. Compounds 8-41 were synthesized to evaluate the SAR in 5-(2- ethenyl substituted)-3(2H)-furanones. Electron-withdrawing substituents on the aromatic ring (8, 10, 19, and 20) gave 2-3-fold higher activity. Further increases in the activity were found when the phenyl ring was replaced by heterocyclic nuclei. Compounds that contained a thiophene (29), pyridine (24- 26), or quinoline ring (32) had the best activity. Replacement of the methyl group on the furanone ring with a phenyl (34) or p-fluorophenyl (40) substituent in the 2-pyridine series gave compounds with activity that ranked with the best obtained in this study. The best compounds from the above SAR studies were evaluated in the ethanol-necrosis model for duration of cytoprotection action. Compounds 19, 24, and 29, which had the best duration of action, were tested with AG-629 in the acidified aspirin and indomethacin- induced lesion models. Only compound 24 had equivalent activity with AG-629 in both models.