71508-68-4Relevant academic research and scientific papers
Quinolinehydrazones as inhibitors of retroviral reverse transcriptase
Bartolucci,Cellai,Di Filippo,Brizzi,Pellerano,Savini,Benedetto,Elia
, p. 945 - 952 (2007/10/02)
The inhibitory activity of a series of 2- and 4-quinolinehydrazones on retroviral reverse transcriptase has been studied on enzymes from M-MuLV, RAV-2, and on a crude lysate of HIV-1, assuming the first two enzymes as potential models of the third. The highest activity is mainly found in lipophilic, water soluble 4-quinolinehydrazones. The inhibitory activity of these compounds decreases in changing from the M-MuLV to the RAV-2, and HIV-1 enzymes, in this order.
