71521-93-2

Upstream product

• 54879-52-6 6,7-dimethoxy-2-(toluene-4-sulfonyl)-1,2-dihydro-isoquinoline 
• 949139-80-4 2-(N-(3,4-dimethoxybenzyl)-4-methylphenyl-sulfonamido)acetyl chloride 
• 208848-88-8 6,7-Dimethoxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3,4-diol 

Relevant academic research and scientific papers

QUINOLINE AND ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS

The present invention is directed to certain quinoline and isoquinoline compounds that are PDElO inhibitors, pharmaceutical compositions containing such compounds and processes for preparing such compounds. The invention is also directed to methods of treating diseases mediated by PDElO enzyme, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

Carbonyl transposition of α-hydroxyamidals mediated by triphenylphosphine-iodine. A new entry to tetrahydroisoquinolin-4-ones

Carbonyl transposition of 2-sulfonyl-3-methoxy-4-hydroxy- tetrahydroisoquinolines with the triphenylphosphine-iodine reagent provides a new access to tetrahydroisoquinolin-4-one derivatives.