71536-99-7

Upstream product

• 71558-02-6 (1S,4aS)-5,5,8a-Trimethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalene-1,2-dicarboxylic acid dimethyl ester 
• 22567-27-7 ((1S,4aR,8aS)-2-Hydroxymethyl-5,5,8a-trimethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl)-methanol 
• 56666-27-4 3,4,4aα,5,6,7,8,8aβ-octahydro-5,5,8aβ-trimethyl-3-oxonaphthalene-2-carboxaldehyde 
• 112320-77-1 2(E)-<(butylthio)methylene>-5,5,8aβ-trimethyl-trans-perhydro-3-oxonaphthalene-1α-carbonitrile 
• 112320-79-3 2-(1,3-dioxolan-2-yl)-1,4,4aα,5,6,7,8,8a-octahydro-5,5,8aβ-trimethylnaphthalene-1α-carbonitril 
• 112320-75-9 2-(hydroxymethylene)-5,5,8aβ-trimethyl-trans-perhydro-3-oxonaphthalene-1α-carbonitrile 
• 112320-78-2 2-formyl-1,4,4aα,5,6,7,8,8aα-octahydro-5,5,8aβ-trimethylnaphthalene-1α-carbonitrile 
• 56666-26-3 3-(hydroxymethylene)-3,4,4a,5,6,7,8,8a-octahydro-4aβ,8,8-trimethylnaohthalene-23(1H)-one 
• 71493-15-7 2-(1,3-dioxolan-2-yl)-1,4,4aα,5,6,7,8,8a-octahydro-5,5,8aβ-trimethylnaphthalene-1α-corboxaldehyde 
• 33118-34-2 polygodial 
• 361544-76-5 5,5,8a-Trimethyl-1,5,6,7,8,8a-hexahydro-naphthalene-1,2-dicarboxylic acid dimethyl ester 
• 71558-02-6 Dimethoxy carbonyl-1,2 trimethyl-5,5,8a Octahydro-1,4,4a,5,6,7,8,8a naphtalene-(1RS, 4aSR, 8aRS) 
• 71557-96-5 dimethyl 3,5,6,7,8,8a-hexahydro-5,5,8a-trimethylnaphthalene-1,2-dicarboxylate 
• 5956-39-8 (1S,4aR,8aS)-5,5,8a-Trimethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalene-1,2-dicarbaldehyde 

Downstream Products

• 5956-39-8 (1R,4aR,8aS)-5,5,8a-Trimethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalene-1,2-dicarbaldehyde 

Relevant academic research and scientific papers

Synthesis of all possible stereoisomers of polygodial

The three possible isomers of polygodial, epimers at C-9, cis and trans fused, are described.Controlled kinetic and thermodynamic epimerizations allow preparation of all stereoisomers from the same key intermediate.

EFFICIENT TOTAL SYNTHESES OF POLYGODIAL AND DRIMENIN.

A short and stereoselective total synthesis of (+/-) polygodial and drimenin is presented.The efficiency of the synthesis is due to the easy access to intermediate diol 4 and its successful direct oxidation into polygodial.