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4-Hydroxy-4(2-hydroxymethylphenyl)-1-piperidine carboxylate is a chemical compound with the molecular formula C14H19NO4. It is a piperidine derivative that features a hydroxy group and a carboxylate group. 4-hydroxy-4（2-hydroxymethylphenyl）-1-piperidine carboxylat holds potential pharmaceutical applications, particularly in the development of medications for treating various health conditions. Its specific uses and effects are contingent upon its pharmacological properties and interactions with biological systems. 4-hydroxy-4（2-hydroxymethylphenyl）-1-piperidine carboxylat's structure and properties have garnered interest among researchers and pharmaceutical companies for the development of new drugs with therapeutic benefits.

71546-51-5

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71546-51-5 Usage

Uses

Used in Pharmaceutical Industry:
4-Hydroxy-4(2-hydroxymethylphenyl)-1-piperidine carboxylate is used as a pharmaceutical intermediate for the development of medications targeting a range of health conditions. Its unique structure and functional groups contribute to its potential as a building block in the synthesis of new therapeutic agents.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 4-hydroxy-4(2-hydroxymethylphenyl)-1-piperidine carboxylate serves as a key compound for studying its interactions with biological targets. This research aids in understanding its pharmacological profile and optimizing its properties for specific therapeutic applications.
Used in Drug Discovery:
4-Hydroxy-4(2-hydroxymethylphenyl)-1-piperidine carboxylate is utilized in drug discovery processes to identify novel drug candidates with potential therapeutic benefits. Its unique chemical structure allows for exploration of various chemical modifications to enhance its efficacy and safety in treating specific health conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 71546-51-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,5,4 and 6 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 71546-51:
(7*7)+(6*1)+(5*5)+(4*4)+(3*6)+(2*5)+(1*1)=125
125 % 10 = 5
So 71546-51-5 is a valid CAS Registry Number.
InChI:InChI=1/C15H21NO4/c1-2-20-14(18)16-9-7-15(19,8-10-16)13-6-4-3-5-12(13)11-17/h3-6,17,19H,2,7-11H2,1H3

71546-51-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 4-hydroxy-4-[2-(hydroxymethyl)phenyl]piperidine-1-carboxylate

1.2 Other means of identification

Product number -
Other names ethyl 4-hydroxy-4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:71546-51-5 SDS

71546-51-5Relevant academic research and scientific papers

METHOD FOR MANUFACTURE OF DIHYDROISOBENZOFURAN DERIVATIVES

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Page 9-10, (2010/02/06)

The present invention relates to a method for the manufacture of dihydroisobenzofurans of formula I; comprising generation a dianion of formula II, reaction of the dianion with a carbonyl compound of formula III and acidification of the reaction mixture t

Spiro-substituted piperidines as neurokinin receptor antagonists. I. Design and synthesis of (±)-N-[2-(3,4-Dichlorophenyl)-4- (spiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl)butyl]-N-methylbenzamide, YM- 35375, as a new lead compound for novel neurokinin receptor antagonists

Kubota, Hirokazu,Fujii, Masahiro,Ikeda, Ken,Takeuchi, Makoto,Shibanuma, Tadao,Isomura, Yasuo

, p. 351 - 354 (2007/10/03)

Analysis of the structural requirements of compound 1 (SR48968), a potent NK2 receptor antagonist, revealed that the 4-phenyl group of the piperidine is essential for binding with the NK2 receptor and occupies an equatorial position. Energy calculation of a variety of substituted 4-phenyl piperidines revealed that spiro[isobenzofuran-1(3H), 4'-piperidine] possesses a conformationally restricted equatorial phenyl group. Our compound 12 (YM- 35375) possessing this spiro-substituted piperidine bound to the NK2 receptor with an IC50 value of 84nM and to the NK1 receptor with an IC50 value of 710nM. It showed more potent inhibitory activity (ID50 41μg/kg (i.v.)) against [β-Ala8]-NKA(4-10)-induced bronchoconstriction in guinea pigs than (±)-SR48968 (ID50 68μg/kg (i.v.)). YM-35375 may be a new lead compound for novel NK2 receptor antagonists or NK1-NK2 dual antagonists.

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