7155-00-2Relevant articles and documents
Regioselective differentiation of vicinal methylene C-H bonds enabled by silver-catalysed nitrene transfer
Scamp, Ryan J.,Scheffer, Bradley,Schomaker, Jennifer M.
supporting information, p. 7362 - 7365 (2019/06/27)
Silver-catalyzed nitrene insertion enables the formation of benzosultams in good yield and with regioselectivity complementary to other transition metal nitrene-transfer catalysts. Preferential formation of six-membered benzosultam rings predominates for alkyl-substituted benzenesulphonamide precursors. Ligand-controlled tunability is also achieved for benzenesulphonamides with γ-branched alkyl substituents. Mechanistic probes suggest that the reaction pathway differs depending on whether a α (benzylic) or β (homobenzylic) C-H bond undergoes amidation, as well as the catalyst identity.
