71566-07-9

Basic information

• Product Name: 5-(4-BROMOPHENYL)-3-METHYL-1,2,4-OXADIAZOLE
• Synonyms: 5-(4-BROMOPHENYL)-3-METHYL-1,2,4-OXADIAZOLE;5-(4-Bromophenyl)-3-methyl-1,2,4-oxadiazole 97%
• CAS NO: 71566-07-9
• Molecular Formula: C₉H₇BrN₂O
• Molecular Weight: 239.07
• Mol File: 71566-07-9.mol

Chemical Properties

• Melting Point: 97 °C
• Boiling Point: 327.9°C at 760 mmHg
• Flash Point: 152.1°C
• Appearance: /
• Density: 1.528g/cm³
• Vapor Pressure: 0.000375mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly)
• PKA: -0.50±0.25(Predicted)
• CAS DataBase Reference: 5-(4-BROMOPHENYL)-3-METHYL-1,2,4-OXADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-BROMOPHENYL)-3-METHYL-1,2,4-OXADIAZOLE(71566-07-9)
• EPA Substance Registry System: 5-(4-BROMOPHENYL)-3-METHYL-1,2,4-OXADIAZOLE(71566-07-9)

Safety Data

• Hazardous Substances Data: 71566-07-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-(4-BROMOPHENYL)-3-METHYL-1,2,4-OXADIAZOLE is used as a reagent for the preparation of cathepsin K inhibitors. Cathepsin K is a protease enzyme that plays a role in bone resorption, and its inhibition can be beneficial in treating conditions related to bone degradation, such as osteoporosis.

InChI:InChI=1/C9H7BrN2O/c1-6-11-9(13-12-6)7-2-4-8(10)5-3-7/h2-5H,1H3

Upstream product

• 71565-90-7 N'-(4-bromo-benzoyl)-N,N-dimethyl-acetamidine 
• 201230-82-2 carbon monoxide 
• 589-87-7 1,4-bromoiodobenzene 
• 118493-85-9 acetamide oxime 
• 698-67-9 p-bromobenzamide 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 18871-66-4 N,N-dimethylacetamide dimethyl acetal 

Downstream Products

• 884198-58-7 (2S)-2-methyl-1-(1-methylethyl)-4-({(3S)-1-[4-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]-3-pyrrolidinyl}carbonyl)piperazine 

Relevant articles and documents

PYRROLIDINE DERIVATIVES AS HISTAMINE RECEPTORS LIGANDS

The present invention relates to pyrrolidine derivatives of formula (I) having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

METHYLENE DIPIPERIDINE DERIVATIVES

The present invention relates to novel methylene dipiperidine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS

The present invention relates to novel piperidine ether derivatives having affinity for the histamine H3 receptor, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

PIPERAZINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISEASES

The present invention relates to novel piperidine carbonyl piperazine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

Novel synthesis of Oxadiazoles via palladium catalysis

Oxadiazoles have been prepared in a one-pot procedure by the palladium- mediated coupling of aryliodides with amidoximes under one atmosphere of carbon monoxide. This reaction proved applicable to both electron-rich and deficient aryliodides.