71566-07-9

Basic information

• Product Name: 5-(4-BROMOPHENYL)-3-METHYL-1,2,4-OXADIAZOLE
• Synonyms: 5-(4-BROMOPHENYL)-3-METHYL-1,2,4-OXADIAZOLE;5-(4-Bromophenyl)-3-methyl-1,2,4-oxadiazole 97%
• CAS NO: 71566-07-9
• Molecular Formula: C₉H₇BrN₂O
• Molecular Weight: 239.07
• Mol File: 71566-07-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 97 °C
• Boiling Point: 327.9°C at 760 mmHg
• Flash Point: 152.1°C
• Appearance: /
• Density: 1.528g/cm³
• Vapor Pressure: 0.000375mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly)
• PKA: -0.50±0.25(Predicted)
• CAS DataBase Reference: 5-(4-BROMOPHENYL)-3-METHYL-1,2,4-OXADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-BROMOPHENYL)-3-METHYL-1,2,4-OXADIAZOLE(71566-07-9)
• EPA Substance Registry System: 5-(4-BROMOPHENYL)-3-METHYL-1,2,4-OXADIAZOLE(71566-07-9)

Safety Data

• Hazardous Substances Data: 71566-07-9(Hazardous Substances Data)

Usage

Uses

5-(4-Bromophenyl)-3-methyl-1,2,4-oxadiazole is a useful reagent for the preparation of cathepsin k inhibitor.

InChI:InChI=1/C9H7BrN2O/c1-6-11-9(13-12-6)7-2-4-8(10)5-3-7/h2-5H,1H3

Upstream product

• 18871-66-4 N,N-dimethylacetamide dimethyl acetal 
• 698-67-9 p-bromobenzamide 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 71565-90-7 N'-(4-bromo-benzoyl)-N,N-dimethyl-acetamidine 
• 201230-82-2 carbon monoxide 
• 589-87-7 1,4-bromoiodobenzene 
• 118493-85-9 acetamide oxime 

Downstream Products

• 884198-58-7 (2S)-2-methyl-1-(1-methylethyl)-4-({(3S)-1-[4-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]-3-pyrrolidinyl}carbonyl)piperazine 

Relevant articles and documents

METHYLENE DIPIPERIDINE DERIVATIVES

The present invention relates to novel methylene dipiperidine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS

The present invention relates to novel piperidine ether derivatives having affinity for the histamine H3 receptor, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

Novel synthesis of Oxadiazoles via palladium catalysis

Oxadiazoles have been prepared in a one-pot procedure by the palladium- mediated coupling of aryliodides with amidoximes under one atmosphere of carbon monoxide. This reaction proved applicable to both electron-rich and deficient aryliodides.