7157-27-9

Upstream product

• 33816-51-2 5-bromo-2-methoxycyclohepta-2,4,6-trien-1-one 

Downstream Products

• 6361-23-5 2,5-dichloro-benzaldehyde 
• 7009-16-7 2-chloro-5-hydroxy-cycloheptatrienone 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 7009-23-6 5-Hydroxy-2-p-tolylsulfanyl-cyclohepta-2,4,6-trienone 
• 7061-38-3 2-Chloro-5-methylamino-cyclohepta-2,4,6-trienone 
• 7009-25-8 4-Amino-7-chlor-tropon 
• 4636-39-9 4-hydroxy-cycloheptatrienone 

Relevant academic research and scientific papers

Regioselective nucleophilic substitution of 5-bromo-2-methoxytropone

The reaction of 5-bromo-2-methoxytropone with O- and N-nucleophiles, such as ethanol/potassium carbonate, sodium hydroxide, diethylamine, propylamine, p-chloroaniline/triethylamine, and p-phenylenediamine/triethylamine, gave corresponding 2-O- and 2-N-substituted troponoids. Alkyl diamines reacted with the substrate to produce bis(2-aminotropone)s. In the case of S-nucleophiles as 1-propanethiol, thiophenol, and 4-aminothiophenol with a base, the regioselective substitution at the 5-position occurred. Halogenation reagents, triphenyldibromophosphorane and its dichloro analogue, furnished 2,5-dibromo- and 2,5-dichlorotropones, respectively.