71571-04-5Relevant academic research and scientific papers
Sulfated tungstate catalyzed activation of nitriles: addition of amines to nitriles for synthesis of amidines
Veer, Sachin D.,Katkar, Kamlesh V.,Akamanchi, Krishnacharya G.
supporting information, p. 4039 - 4043 (2016/08/18)
An efficient and mild method for the synthesis of amidines by direct nucleophilic addition of amines to nitriles using sulfated tungstate as heterogeneous catalyst is described. Highlight of the method is its applicability for the synthesis of amidines using a wide variety of amines including ammonia as ammonium acetate and nitriles. Catalyst is mildly acidic, stable, easy to prepare and separate from the reaction mass.
Copper-catalyzed aerobic aliphatic C-H oxygenation directed by an amidine moiety
Wang, Yi-Feng,Chen, Hui,Zhu, Xu,Chiba, Shunsuke
supporting information; experimental part, p. 11980 - 11983 (2012/09/08)
A method for the oxygenation of tertiary C-H bonds of N-alkylamidines and N-(2-alkylaryl)amidines is described that utilizes the CuBr?SMe 2/2,2′-bipyridine catalytic system under an O2 atmosphere and provides dihydrooxazoles and 4H-1,3-benzoxazines. The oxygen atom is incorporated from atmospheric molecular oxygen during the present process.
Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists.
Curtis, Neil R,Diggle, Helen J,Kulagowski, Janusz J,London, Clare,Grimwood, Sarah,Hutson, Peter H,Murray, Fraser,Richards, Pawel,Macaulay, Alison,Wafford, Keith A
, p. 693 - 696 (2007/10/03)
Novel (E)-N(1)-(benzyl)cinnamamidines were prepared and evaluated as NR2B subtype NMDA receptor ligands. Excellent affinity was achieved by appropriate substitution of either phenyl ring. The 2-methoxybenzyl compound 1h had approximately 1,000-fold lower IC(50) in NR2B than NR2A-containing cells. Replacement of the styryl unit by 2-naphthyl was well tolerated.
