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Upstream product

• 27894-50-4 methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride 
• 25163-98-8 4-isobutyl-2-phenyloxazol-5(4H)-one 
• 24498-31-5 (S)-methyl 2-amino-6-(benzyloxycarbonylamino)hexanoate 
• 1466-83-7 N-benzoyl-L-leucine 

Relevant academic research and scientific papers

Use of polymer-bound 4-dialkylaminopyridines in peptide synthesis

This work describes the use of polymer-bound 4-dialkylaminopyridines as catalyst in peptide bond formation.In comparison with their soluble analogues, such as DMAP, these less basic compounds are less favorable to formation of oxazolone intermediate, and lead to peptide bond formation in good yields, and generally very low racemization. Key words: DMAP; polymer-bound dialkylaminopyridines; peptide synthesis; racemization.

ETUDE DE LA RACEMISATION INDUITE PAR LA DMAP DANS LES REACTIONS DE COUPLAGE PEPTIDIQUE

The scope and limitation for the use of 4-dimethyalmino pyridine (DMAP) as additive to carbodiimides in peptide synthesis are studied and compared with the results obtained with N-hydroxybenzotriazole (HOBt).The activation of N-acylated aminoacids by the

THE DEPENDENCE OF ASYMMETRIC INDUCTION ON SOLVENT POLARITY AND TEMPERATURE IN PEPTIDE SYNTHESIS

When a racemic 2,4-dialkyl-5(4H)-oxazolone reacts with an L-amino acid ester, the D-L epimer is formed in excess in apolar solvents and the L-L epimer is formed in excess in polar solvents, the proportion of L-L isomer increasing with decreasing temperature.