71589-39-4

Basic information

• Product Name: (+)-2-[4-[(isobut-2-enyl)amino]phenyl]propionic acid
• Synonyms: (+)-2-[4-[(isobut-2-enyl)amino]phenyl]propionic acid;d-Alminoprofen;(+)-2-[4-(Methallylamino)phenyl]propionic acid;(+)-4-(Methallylamino)-α-methylbenzeneacetic acid;2-((+)-p-Methallylaminophenyl)propionic acid;Einecs 275-648-2
• CAS NO: 71589-39-4
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.27958
• EINECS: 275-648-2
• Mol File: 71589-39-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 373.1±30.0 °C(Predicted)
• Appearance: /
• Density: 1.107±0.06 g/cm3(Predicted)
• PKA: 4.86±0.50(Predicted)
• CAS DataBase Reference: (+)-2-[4-[(isobut-2-enyl)amino]phenyl]propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-2-[4-[(isobut-2-enyl)amino]phenyl]propionic acid(71589-39-4)
• EPA Substance Registry System: (+)-2-[4-[(isobut-2-enyl)amino]phenyl]propionic acid(71589-39-4)

Safety Data

• Hazardous Substances Data: 71589-39-4(Hazardous Substances Data)

Usage

General Description

(+)-2-[4-[(isobut-2-enyl)amino]phenyl]propionic acid is a chemical compound with the molecular formula C13H17NO2. It is a non-steroidal anti-inflammatory drug (NSAID) and is commonly known as ibuprofen. Ibuprofen is a medication used to reduce pain, fever, and inflammation. It works by inhibiting the production of prostaglandins, which are hormone-like substances that play a role in inflammation and pain. Ibuprofen is commonly used to treat conditions such as headache, menstrual cramps, arthritis, and muscle aches. It is available over-the-counter and is considered to be a safe and effective medication when used as directed. Ibuprofen is one of the most widely used NSAIDs in the world and has been on the market for over 50 years.

Upstream product

• 362052-00-4 2-(4-cyano-phenyl)-propionic acid 

Relevant articles and documents

Boryl Radical Activation of Benzylic C-OH Bond: Cross-Electrophile Coupling of Free Alcohols and CO2via Photoredox Catalysis

A new strategy for the direct cleavage of the C(sp3)-OH bond has been developed via activation of free alcohols with neutral diphenyl boryl radical generated from sodium tetraphenylborate under mild visible light photoredox conditions. This strategy has been verified by cross-electrophile coupling of free alcohols and carbon dioxide for the synthesis of carboxylic acids. Direct transformation of a range of primary, secondary, and tertiary benzyl alcohols to acids has been achieved. Control experiments and computational studies indicate that activation of alcohols with neutral boryl radical undergoes homolysis of the C(sp3)-OH bond, generating alkyl radicals. After reducing the alkyl radical into carbon anion under photoredox conditions, the following carboxylation with CO2 affords the coupling product.

Phenylacetic acid derivatives

The present invention relates to phenylacetic acid derivatives having the general formula: SPC1 In which R1 represents a lower alkyl radical, a lower alkenyl radical, a lower alkynyl radical or an aryl(lower) alkyl radical, R2 represents hydrogen or a methyl radical, their esters and their salts with bases and acids. Said derivatives have in particular an analgesic and/or anti-inflammatory activity.