71603-41-3 Usage
24,24-difluoro-25-hydroxyvitamin D3
Synthetic derivative of vitamin D3
Contains two fluorine atoms at the 24th position and a hydroxyl group at the 25th position
Primarily used for research purposes
Shows potential as a therapeutic agent for the treatment of osteoporosis, cancer, and autoimmune disorders
Exhibits enhanced metabolic stability and biological activity compared to natural vitamin D3
Promising candidate for the development of new pharmaceuticals targeting vitamin D receptor-mediated pathways
Can effectively regulate calcium and phosphate levels in the body
Modulates immune function and cell growth
Check Digit Verification of cas no
The CAS Registry Mumber 71603-41-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,6,0 and 3 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 71603-41:
(7*7)+(6*1)+(5*6)+(4*0)+(3*3)+(2*4)+(1*1)=103
103 % 10 = 3
So 71603-41-3 is a valid CAS Registry Number.
InChI:InChI=1/C27H42F2O2/c1-18-8-11-22(30)17-21(18)10-9-20-7-6-15-26(5)23(12-13-24(20)26)19(2)14-16-27(28,29)25(3,4)31/h9-10,19,22-24,30-31H,1,6-8,11-17H2,2-5H3/b20-9+,21-10-/t19-,22-,23?,24+,26-/m1/s1
71603-41-3Relevant academic research and scientific papers
Studies on Organic Fluorine Compounds. Part 37. Studies on Steroids. Part 78. Synthesis of 24,24-Difluoro- and 24ξ-Fluoro-25-hydroxyvitamin D3
Kobayashi, Yoshiro,Taguchi, Takeo,Terada, Tadafumi,Oshida, Jun-ichi,Morisaki, Masuo,Ikekawa, Nobuo
, p. 85 - 92 (2007/10/02)
To clarify the physiological significance of C-24 hydroxylation in vitamin D3 metabolism , vitamin D3 compounds blocked at C-24 by fluorine substituents, namely 24,24-difluoro-25-hydroxyvitamin D3 (1) and 24ξ-fluoro-25-hydroxyvitamin D3 (2) have been synthesized from 3β-hydroxychol-5-en-24-oic acid (13).
