716163-47-2

Basic information

• Product Name: (2S,3S)-3-benzyloxy-1,2-O-isopropylidene-4-(4-methoxycarbonyl-1,2,3-triazol-1-yl)-1,2-butanediol
• Synonyms: (2S,3S)-3-benzyloxy-1,2-O-isopropylidene-4-(4-methoxycarbonyl-1,2,3-triazol-1-yl)-1,2-butanediol
• CAS NO: 716163-47-2
• Molecular Weight: 361.398
• Mol File: 716163-47-2.mol

Chemical Properties

• CAS DataBase Reference: (2S,3S)-3-benzyloxy-1,2-O-isopropylidene-4-(4-methoxycarbonyl-1,2,3-triazol-1-yl)-1,2-butanediol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-3-benzyloxy-1,2-O-isopropylidene-4-(4-methoxycarbonyl-1,2,3-triazol-1-yl)-1,2-butanediol(716163-47-2)
• EPA Substance Registry System: (2S,3S)-3-benzyloxy-1,2-O-isopropylidene-4-(4-methoxycarbonyl-1,2,3-triazol-1-yl)-1,2-butanediol(716163-47-2)

Safety Data

• Hazardous Substances Data: 716163-47-2(Hazardous Substances Data)

Upstream product

• 922-67-8 propynoic acid methyl ester 
• 143365-04-2 (2S,3S)-4-azido-3-benzyloxy-1,2-O-isopropylidene-1,2-butanediol 

Downstream Products

• 716162-31-1 dimethyl (1R,2S)-2-benzyloxy-1-hydroxy-3-(4-methoxycarbonyl-1,2,3-triazol-1-yl)propylphosphonate 
• 716162-84-4 dimethyl (1S,2S)-2-benzyloxy-1-hydroxy-3-(4-methoxycarbonyl-1,2,3-triazol-1-yl)propylphosphonate 
• 716164-01-1 1-(2-benzyloxy-3-oxo-propyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester 
• 716163-73-4 (2S,3S)-3-benzyloxy-4-(4-methoxycarbonyl-1,2,3-triazol-1-yl)-1,2-butanediol 

Relevant articles and documents

Synthesis of (1R,2S)- and (1S,2S)-3-(4-carbamoyl-1,2,3-triazol-1-yl)-1,2- dihydroxypropylphosphonates

Good regioselectivity (86:14 and 80:20) was observed in the 1,3-dipolar cycloaddition of methyl propiolate to diastereoisomeric dimethyl (1R,2S)- and (1S,2S)-3-azido-2-benzyloxy-1-hydroxypropylphosphonates. The major 4-methoxycarbonyl regioisomers were transformed into O-methyl (1R,2S)- and (1S,2S)-3-(4-carbamoyl-1,2,3-triazol-1-yl)-1,2-dihydroxypropylphosphonic acids, structural analogues of ribavirin.