71641-10-6

Basic information

• Product Name: 4-Benzofurancarboxylic acid,2-methyl-
• Synonyms: 2-methyl-4-benzofurancarbonsaeure;2-methyl-benzofuran-4-carboxylic acid;2-Methyl-4-anilino-5-hydroxymethyl-pyrimidin
• CAS NO: 71641-10-6
• Molecular Formula: C10H8O3
• Molecular Weight: 176.172
• Mol File: 71641-10-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 189-190 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 342.7±22.0 °C(Predicted)
• Density: 1.303±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-Benzofurancarboxylic acid,2-methyl- (CAS DataBase Reference)
• NIST Chemistry Reference: 4-Benzofurancarboxylic acid,2-methyl- (71641-10-6)
• EPA Substance Registry System: 4-Benzofurancarboxylic acid,2-methyl- (71641-10-6)

Safety Data

• Hazardous Substances Data: 71641-10-6(Hazardous Substances Data)

Upstream product

• 160893-68-5 m-methoxycarbonylphenyl propargyl ether 
• 79950-40-6 methyl 2,3-dihydro-2-methylbenzofuran-4-carboxylate 
• 71641-09-3 2-methylbenzofuran-4-carbaldehyde 
• 133844-99-2 2-methyl-4-benzofurancarbonsaeuremethylester 

Downstream Products

• 1261963-84-1 C₂₁H₂₁ClN₂O₃ 
• 1261963-86-3 C₂₁H₂₁ClN₂O₃ 
• 1261963-88-5 C₂₁H₂₁ClN₂O₃ 
• 1261963-89-6 C₂₁H₂₀Cl₂N₂O₃ 
• 1261963-90-9 C₂₁H₂₀N₄O₇ 
• 1261963-93-2 C₂₃H₂₆N₂O₃ 
• 1204583-41-4 rac-2-methyl-benzofuran-4-carboxylic acid [3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-thiazolidin-2-ylmethyl]-amide 

Relevant articles and documents

Synthesis, crystal structures, insecticidal activities, and structure-activity relationships of novel N ′- Tert -Butyl- N ′-substituted-benzoyl- N -[di(octa)hydro]benzofuran{(2,3-dihydro)benzo[1, 3]([1,4])dioxine}carbohydrazide derivatives

Several series of novel N′-tert-butyl-N′-substituted-benzoyl-N- [di(octa)hydro]benzofuran{(2,3-dihydro)benzo[1,3]([1,4])dioxine}carbohydrazide derivatives Ia, Ib, IIa-IIg, IIIa, IIIb, and Va-Vc were designed and synthesized. Their structures were confirmed by 1H NMR spectra, HRMS, and X-ray single-crystal structures. The larvicidal activities against oriental armyworm, beet armyworm, diamond-back moth, and corn borer of these compounds were evaluated and contrasted with those of RH-2485, JS-118, and ANS-118. The larvicidal activities against oriental armyworm indicate that monosubstituent or multisubstituents and the substituting group position cannot promote increasing activities and that the cycle region in the general structure of IIa-IIg is much more sensitive to activity than that in the general structure of Ia and Ib. The space volume of the A ring in the structure of Va cannot be too large; if it is, the activity will be decreased significantly. Stomach toxicities against beet armyworm, diamond-back moth, and corn borer of compounds Ia, Ib and IIg indicate that benzoheterocyclic analogues of N-tert-butyl-N,N′- diacylhydrazines show significant selectivities to different lepidopterous pests.

AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to novel azetidine compounds of formula (I), wherein R1, R2, and X are as described in the description and their use as orexin receptor antagonists.