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Usage

Uses

Used in Skincare Products:
2,2-Dimethylchroman-4-ol is used as an antioxidant in skincare products for its ability to protect the skin from UV damage and premature aging. It is commonly added to moisturizers, sunscreens, and anti-aging formulations to nourish the skin and maintain its youthful appearance.
Used in Dietary Supplements:
In the dietary supplement industry, 2,2-Dimethylchroman-4-ol is used as a nutrient to provide immune support and promote overall health. Its antioxidant properties contribute to the maintenance of a robust immune system and general well-being.
However, it is important to note that the safety of 2,2-Dimethylchroman-4-ol, particularly when used in vaping products, has been a subject of concern due to its association with severe lung injuries in some cases. Further research and regulatory oversight are necessary to ensure its safe application in various industries.

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 3780-33-4 2,3-dihydro-2,2-dimethylbenzo[b]pyran-4-one 
• 100942-29-8 2,2-dimethyl-4-keto-7-tosyloxy-benzopyran 
• 62113-84-2 7-methanesulfonyloxy-2,2-dimethyl-chroman-4-one 

Downstream Products

• 1630952-60-1 8-(2,2-dimethylchroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one 
• 58740-82-2 (3S,4S)-3,4-epoxy-2,2-dimethylchromane 
• 58740-82-2 (3R,4R)-3,4-epoxy-2,2-dimethylchromane 
• 264265-13-6 bis[4-(dimethylamino)phenyl](2,2-dimethyl-3-chromenyl)methanol 
• 264264-98-4 bis[4-(dimethylamino)phenyl](2,2-dimethyl-5-chromenyl)methanol 

Relevant academic research and scientific papers

Transfer Hydrogenation of Carbonyl Derivatives Catalyzed by an Inexpensive Phosphine-Free Manganese Precatalyst

A very simple and inexpensive catalytic system based on abundant manganese as transition metal and on an inexpensive phosphine-free bidendate ligand, 2-(aminomethyl)pyridine, has been developed for the reduction of a large variety of carbonyl derivatives with 2-propanol as hydrogen donor. Remarkably, the reaction proceeds at room temperature with low catalyst loading (down to 0.1 mol %) and exhibits a good tolerance toward functional groups. High TON (2000) and TOF (3600 h-1) were obtained.

Synthesis, enantiomeric separation and docking studies of spiropiperidine analogues as ligands of the nociceptin/orphanin FQ receptor

A series of triazospirodecanone derivatives were synthesized as potential NOP ligands. 8-(Chroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (4) and its 5-fluoro analogue (18) proved to be active as agonists with EC50 values in the submicromolar range. Single enantiomers of compound 4 were separated and tested as NOP agonists; the eutomer R-(+)-4 showed a pEC 50 of 7.34. Finally docking studies were performed on the NOP receptor to identify the most significant stereospecific interactions.

Silylation-based kinetic resolution of monofunctional secondary alcohols

The nucleophilic small molecule catalyst (-)-tetramisole was found to catalyze the kinetic resolution of monofunctional secondary alcohols via enantioselective silylation. Optimization of this new methodology allows for selectivity factors up to 25 utilizing commercially available reagents and mild reaction conditions.

1,2,3,4-Tetrahydropyrazin-2-yl acetamides and methods of use

Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and

Synthesis and activity of novel and selective Iks-channel blockers

Since the discovery of the IKs-potassium channel as the slowly activating component of the delayed rectifier current (Ik) in cardiac tissue, the search for blockers of this current has been intense. During the screening of KATP

Reverse asymmetric catalytic epoxidation of unfunctionalized alkenes

New salen Mn(III) complexes (S,S)-6a-e prepared from tartaric-derived alicyclic C2 symmetric vicinal diamines were studied in the catalysis of the asymmetric epoxidation of unfunctionalized alkenes. Although the enantioselectivities obtained we

Chromenes and chromanones. Part IV.1 The Birch reduction of 2,2-dimethyl-4-chromanone and its 7-substituted analogues

2,2-Dimethyl-4-chromanone (1a), 2,2,7-trimethyl-4-chromanone (1b) and 7-methoxy-2,2-dimethyl-4-chromanone (1c) have been reduced by sodium or lithium in liquid ammonia with the presence or without of proton donor. The bicyclic or phenolic products were obtained. Products with reduced benzene ring only were also observed. The possible mechanisms of reductions are considered.

Modification of hydroxybenzopyranoids: Facile deoxygenation of 2,2-dimethyl-7-hydroxy-4-chromanones and a new approach to their novel mercapto analogs

A facile deoxygenation of a systematic series of substituted 2,2-dimethyl-7-hydroxy-4-chromanones via their sulfonate, isourea, and thiocarbamate derivatives is reported. The synthesis of novel 2,2-dimethyl-7-mercapto-4-chromanones has been accomplished b

Unsaturated N-benzopyranyllactams

Compounds I STR1 where R1 is H, alkyl, alkoxy, CO alkyl, COOH, carboxyalkyl, CONR2, CN, NO2, alkylsulfi(o)nyl, arylsulfi(i)-nyl; R2 is H, OH, alkoxy, alkyl or alkylcarbonyl, R3 /R4 are alky