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[(2Z)-4-amino-1-(2-cyanoethyl)-5,6-dihydropyrimidin-2(1H)-ylidene]cyanamide, also known as Lometrexol, is a synthetic chemical compound with potent antifolate and antineoplastic properties. It functions by inhibiting the enzyme glycinamide ribonucleotide formyltransferase, which plays a crucial role in the synthesis of purine nucleotides. This inhibition disrupts DNA and RNA synthesis, thereby inhibiting cell growth and making Lometrexol a promising candidate for cancer treatment.

71655-83-9

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71655-83-9 Usage

Uses

Used in Anticancer Applications:
Lometrexol is used as an antineoplastic agent for the treatment of various types of cancer, particularly solid tumors. It has been studied for its potential in treating lung, breast, and ovarian cancers. [(2Z)-4-amino-1-(2-cyanoethyl)-5,6-dihydropyrimidin-2(1H)-ylidene]cyanamide's mechanism of action involves the inhibition of key enzymes in nucleotide synthesis, leading to the disruption of cellular processes and the suppression of tumor growth.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Lometrexol is utilized as an active pharmaceutical ingredient in the development of cancer therapeutics. Its unique mechanism of action and potential for treating various types of cancer make it a valuable compound for research and drug development efforts.
Used in Clinical Trials:
Lometrexol is used in clinical trials to evaluate its safety, efficacy, and potential side effects as a treatment for cancer. These trials are essential for determining the optimal dosage, administration method, and overall effectiveness of the compound in treating specific types of cancer.
Used in Drug Formulation:
Lometrexol is also used in the formulation of cancer treatment drugs, where it is combined with other active ingredients or supportive therapies to enhance the overall treatment strategy. This may involve the development of combination therapies or the use of Lometrexol as a component in a broader treatment regimen.

Check Digit Verification of cas no

The CAS Registry Mumber 71655-83-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,6,5 and 5 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 71655-83:
(7*7)+(6*1)+(5*6)+(4*5)+(3*5)+(2*8)+(1*3)=139
139 % 10 = 9
So 71655-83-9 is a valid CAS Registry Number.

71655-83-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name [6-amino-3-(2-cyanoethyl)-4,5-dihydropyrimidin-2-ylidene]cyanamide

1.2 Other means of identification

Product number -
Other names 3-(4-amino-2-cyanoimino-5,6-dihydropyrimidin-1-yl)propanenitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:71655-83-9 SDS

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