71666-57-4

Basic information

• Product Name: Benzamide, N-[(2-oxocyclohexyl)methyl]-
• CAS NO: 71666-57-4
• Molecular Formula: C14H17NO2
• Molecular Weight: 231.294
• Mol File: 71666-57-4.mol

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[(2-oxocyclohexyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[(2-oxocyclohexyl)methyl]-(71666-57-4)
• EPA Substance Registry System: Benzamide, N-[(2-oxocyclohexyl)methyl]-(71666-57-4)

Safety Data

• Hazardous Substances Data: 71666-57-4(Hazardous Substances Data)

Upstream product

• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 670-80-4 4-cyclohexen-1-ylmorpholine 
• 111184-75-9 N-(1H-benzotriazol-1-ylmethyl)benzamide 
• 495-69-2 Hippuric Acid 
• 1019770-60-5 BF₄^(1-)*C₂₆H₂₃NOP⁽¹⁺⁾ 
• 21300-30-1 lithium 1-cyclohexenolate 

Downstream Products

• 300678-86-8 2-(1-morpholinocyclohexyl)cyclohexanol 

Relevant articles and documents

Amidoalkylating properties of 1-(N -acylamino)alkyltriphenylphosphonium salts

Easily accessible 1-(N-acylamino)alkyltriphenylphosphonium salts react smoothly with nitrogen, sulfur, phosphorus and oxygen nucleophiles in the presence of (i-Pr)2EtN to give the expected α-amidoalkylation products, usually in good or very good yields. α-Amidoalkylation of dialkyl malonates or acetylacetates requires the application of a much stronger base (DBU) and gives the best results under the influence of microwave irradiation. α-Amidoalkylation of enamines was carried out successfully in the presence of (i-Pr)2EtN in a microwave reactor. 1-(N-Acylamino)alkyltriphenylphosphonium salts can be considered as new, convenient and effective α-amidoalkylation agents.

Preparation of β-amido ketones and aldehydes via amidoalkylation of enamines, enol silyl ethers, and vinyl ethers

Novel syntheses of β-amidoalkyl ketones and aldehydes via amidoalkylations of enamines, silyl enol ethers, and vinyl ethers with N-(1- benzotriazol-1-ylalkyl)amides are described.

Benzotriazole-assisted synthesis of novel mannich bases from ketones and diverse aldehydes

A wide variety of β-amino ketones are prepared in moderate to good yields by the reaction of the lithium enolates of cyclohexanone, acetophenone, α-tetralone and camphor with the readily available adducts from an aldehyde or ketone, an amine and benzotriazole. Some diastereoselectivity is observed when the benzotriazole adduct is derived from benzaldehyde.