7168-94-7

Upstream product

• 19829-72-2 2,3-dihydroxyterephthalic acid 
• 77-78-1 dimethyl sulfate 
• 75956-62-6 dimethyl 2,3-dihydroxyterephthalate 
• 74-88-4 methyl iodide 
• 120-80-9 benzene-1,2-diol 
• 75956-61-5 disodium 2,3-dihydroxyterephthalate 

Downstream Products

• 75956-63-7 sodium methyl 2,3-dimethoxyterephthalate 
• 7168-95-8 2,3-dimethoxyterephthalic acid 
• 179693-85-7 2,3-dimethoxy-1,4-benzenedicarboxaldehyde 
• 341556-94-3 3,3'-(2,3-dimethoxy-1,4-phenylene)bisacrylic acid 
• 908339-19-5 4-hydroxymethyl-6-iodo-2,3-dimethoxy-benzoic acid methyl ester 
• 350245-32-8 5-iodo-2,3-dimethoxy-terephthalic acid 4-methyl ester 
• 350245-26-0 5-iodo-2,3-dimethoxy-terephthalic acid dimethyl ester 
• 350245-33-9 4-((tert-butyldimethylsilanyl)oxymethyl)-6-iodo-2,3-dimethoxybenzoic acid methyl ester 
• 350245-27-1 2,3-bis-benzyloxy-5-iodo-terephthalic acid dimethyl ester 
• 350245-30-6 2,3-bis-benzyloxy-5-iodo-terephthalic acid 
• 350245-28-2 2,3-bis-benzyloxy-5-(3-hydroxy-prop-1-ynyl)-terephthalic acid dimethyl ester 
• 350245-38-4 2,3-bis-benzyloxy-5-[3-(tert-butyl-dimethyl-silanyloxy)-prop-1-ynyl]-terephthalic acid dimethyl ester 
• 75956-64-8 2,3-Dimethoxy-4-(methoxycarbonyl)benzoylchlorid 
• 92078-25-6 2,2',2,3,3',3-hexahydroxy-4,4',4-<1,3,5-benzenetriyltris(methyleniminocarbonyl)>tris benzoic acid 

Relevant academic research and scientific papers

Experimental, Structural, and Computational Investigation of Mixed Metal-Organic Frameworks from Regioisomeric Ligands for Porosity Control

Porosity control and structural analysis of metal-organic frameworks (MOFs) can be achieved using regioisomeric ligand mixtures. While ortho-dimethoxy-functionalized MOFs yielded highly porous structures and para-dimethoxy-functionalized MOFs displayed almost nonporous properties in their N2 isotherms after evacuation, regioisomeric ligand-mixed MOFs showed variable N2 uptake amount and surface area depending on the ligand-mixing ratio. The quantity of N2 absorbed was tuned between 20 and 300 cm3/g by adjusting the ligand-mixing ratio. Both experimental analysis and computational modeling were performed to understand the porosity differences between ortho- A nd para-dimethoxy-functionalized MOFs. Detailed structural analysis using X-ray crystallographic data revealed significant differences in the coordination environments of DMOF-[2,3-(OMe)2] and DMOF-[2,5-(OMe)2] (DMOF = dabco MOF, dabco = 1,4-diazabicyclo[2.2.0]octane). The coordination bond between Zn2+ and carboxylate in the ortho-functionalized DMOF-[2,3-(OMe)2] was more rigid than that in the para-functionalized DMOF-[2,5-(OMe)2]. Quantum-chemical simulation also showed differences in the coordination environments of Zn secondary building unit surrounded by methoxy-functionalized ligands and pillar ligands. In addition, the binding energy differences between Zn2+ and regioisomeric ligands (ortho- A nd para-dimethoxy-functionalized benzene-1,4-dicarboxylates) explained the rigidity and porosity changes of the mixed MOFs upon evacuation and perfectly matched with experimental N2 adsorption and X-ray crystallography data.

Novel seco cyclopropa[c]pyrrolo[3,2-e]indole bisalkylators bearing a 3,3′-arylenebisacryloyl group as a linker

We synthesized the novel seco cyclopropa[c]pyrrolo[3,2-e]indole (CPI) bisalkylators and evaluated their antitumor activity. Among these derivatives, 11a (AT-760), in which the two seco 3-methoxycarbonyl-2-trifluoromethyl CPI (MCTFCPI) moieties are connected with a 3,3′-(1,4-phenylene)bisacryloyl group, was found to exhibit more potent cytotoxicity and antitumor activity against HeLaS3 human uterine cervix carcinoma cells and Colon 26 adenocarcinoma cells, respectively, than 8 (bizelesin, U-77,779). It also appeared that compound 11a exhibits improved in vivo efficacy in the human colon CX-1 model when compared to either compound 8 or mitomycin C (MMC). Efficacious doses for 11a were found to be 2-fold lower than those for 8.

Synthesis of the isocoumarin portion of the rubromycins

A synthesis of the isocoumarin found in the rubromycin class of natural products is reported. The isocoumarin ring system is formed via Heck coupling of a pyruvate synthon with a terephthalic acid derivative followed by an intramolecular acid-catalyzed cyclization. The requisite terephthalic acid precursor is generated by carboxylation of catechol and then desymmetrization of the aromatic ring by halogenation. The isocoumarin derivative that has been produced is an appropriate precursor for the synthesis of γ-rubromycin, purpuromycin, and heliquinomycin.

Electroorganic reactions. Part 55. Quinodimethane chemistry. Part 3. Transition metal complexes as inter- and intra-molecular redox catalysts for the electrosynthesis of poly(p-xylylene) (PPX) polymers and oligomers

The role of metal complexes as redox mediators in the electrosynthesis of poly(p-xylylenes) (PPXs) has been explored, with a view to designing metal-containing precursors that can act both as mediators and starting materials for metal-containing polymers. A number of transition metal complexes [Cr(III), Ni(II) and Co(II)] are efficient redox catalysts for production of quinodimethanes, and hence PPXs. Following encouraging results from experiments using mediators based on anthranilic acid and salicylaldehyde ligands a macrocyclic compound was designed, and successfully prepared by a convergent route that incorporated both a 1,4-bis(chloromethylarene) function as a precursor to a quinodimethane and a Ni(II) salen unit as an intramolecular redox catalyst. The macrocycle was successfully reduced cathodically to yield a PPX polymer with bound Ni(II). Evidence is presented for the operation of intramolecular redox catalysis (homomediation).

Acrylamide derivatives and process for production thereof

Acrylamide derivatives represented by General Formula (1) below: STR1 (One specific example of General Formula (1) is methyl (S,S)-3,3'-?3,3'-(1,4-phenylenediacryloyl)!-bis?1-chloromethyl-5-hydroxy-7-triflouromethyl-1, 2,3,6-tetrahydropyrrolo?3,2-e!indole-8-carboxylate.) The acrylamide derivatives represented by General Formula (1) is highly selective to cancer cells, less toxic, and highly active also against solid tumor.

Polycatecholamide chelating agents

Novel polybenzamide compounds useful for in vitro or in vivo chelation are described. The compounds have the formula STR1 Polyamines are reacted with 2,3-dimethoxy benzoyl chloride unsubstituted or substituted with SO3 H, SO3 M, NO2, CO2 H or CO2 M as desired is reacted with a polyamine in an inert solvent then demethylated with BBr3 or BCl3 in an inert solvent. Where compounds symmetrically substituted on the terminal N's are desired, the polyamine is first reductively alkylated by reaction with an aldehyde or ketone and the resulting Schiff base is hydrogenated.

Synthetic Enterobactin Analogues. Carboxamido-2,3-dihydroxyterephthalate Conjugates of Spermine and Spermidine

Two examples of a new class of synthetic polycatecholate ligands, the carboxamido-2,3-dihydroxyterephthalate conjugates of spermine (8) and spermidine (10), have been synthesized via the generally useful synthon methyl-2,3-dimethoxyterephthaloyl chloride (6).Initial biological evaluation reveals tetrameric terephthalate (8) to be an extremely effective agent for sequestering and removing plutonium from mice; a single 25-μmol/kg (ip) dose of 8 removed 73percent of the plutonium citrate previously injected (iv,1h earlier).Under the same conditions, trimeric terephthalate (10) ex creted only 49percent injected plutonium.In vitro kinetic experiments have shown that 10 rapidly and quantitatively removed Fe from human transferrin.These results are discussed in relation to the design of metal-ion specific sequestering agents.