71700-93-1

Basic information

• Product Name: 1,4-Naphthalenedione, 5-hydroxy-2-(phenylthio)-
• CAS NO: 71700-93-1
• Molecular Formula: C16H10O3S
• Molecular Weight: 282.32
• Mol File: 71700-93-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,4-Naphthalenedione, 5-hydroxy-2-(phenylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Naphthalenedione, 5-hydroxy-2-(phenylthio)-(71700-93-1)
• EPA Substance Registry System: 1,4-Naphthalenedione, 5-hydroxy-2-(phenylthio)-(71700-93-1)

Safety Data

• Hazardous Substances Data: 71700-93-1(Hazardous Substances Data)

Upstream product

• 4923-57-3 2-chlorojuglone 
• 882-33-7 diphenyldisulfane 
• 83-56-7 1,5-dihydroxynaphthalene 
• 481-39-0 5-hydroxynaphtho-1,4-quinone 
• 108-98-5 thiophenol 
• 77189-69-6 5-acetoxy-2-bromo-1,4-naphthoquinone 
• 69008-03-3 2-bromo-5-hydroxy-[1,4]naphthoquinone 
• 71700-92-0 5-acetoxy-2-(phenylthio)-1,4-naphthoquinone 

Downstream Products

• 112740-64-4 (1R^*,4aR^*,9aR^*)-5-methoxy-9a-(phenylthio)-1-<(trimethylsilyl)oxy>-1,4,4a,9a-tetrahydro-9,10-anthraquinone 
• 112740-65-5 (4aR^*,9aR^*)-5-methoxy-1-oxo-9a-(phenylthio)-1,4,4a,9a-tetrahydro-9,10-anthraquinone 
• 52869-21-3 1-hydroxy-5-methoxy-9,10-anthraquinone 
• 6448-90-4 1,5-dimethoxy-anthraquinone 
• 105259-49-2 5-methoxy-2-(phenylthio)-1,4-naphthoquinone 

Relevant articles and documents

Synthesis, molecular docking, and biological activity of thioether derived from juglone in preclinical models of chronic myeloid leukemia

In this work, 16 new thio-1,4-naphthoquinones were synthesized, and their antiproliferative effects against tumor cell lines SK-MEL-19, AGP-01, ACP-02, HL-60, K-562, K-562-Lucena-1, FEPS, and non-neoplastic human fibroblast MRC-5, were examined. The compounds were selective active against leukemia cell lines. Based on the screening results for cytotoxic activity, naphthoquinone 11a showed higher cytotoxicity on the chemoresistant leukemia (FEPS) cell line when compared to the chemosensitive (K-562) cell line. Moreover, naphthoquinone 11a presented excellent ADME/T and did not violate Lipinski's rule of five, indicating good oral absorption. Target prediction revealed DNA topoisomerase I (TOP1) as a possible target of 11a. The molecular docking prediction showed an ? 11.94 kcal/mol binding affinity interaction of 11a with TOP1, involving three hydrogen bonds to ARG364, A113, and G11 from the active site of the enzyme. In addition, naphthoquinone 11a significantly suppressed the expression of the TOP1 gene in K-562 and FEPS leukemia cell lines. The naphthoquinone 11a induced significant changes in cell morphology, demonstrating cell and nuclear shrinkage, blebbing formation as well and fragmentation of the cell into apoptotic bodies. Thus, 11a could be a drug that leads to a new set of TOP1 major inhibitors. In summary, the present study showed a cytotoxic effect of 11a against chemoresistant and chemosensitive leukemia cell lines with TOP1 as a possible target.

Green synthesis of thiophenyl-1,4-naphthoquinones

Reaction of 1,4-naphthoquinones adsorbed on neutral alumina to thiophenols in ambient conditions gave respective mono thiophenyl 1,4-naphthoquinones regioselectively in quantitative yield. The solvent free synthesis and quantitative conversion makes the process practical method.

Regioselective synthesis of 2- and 3-(Phenylthio)juglone derivatives

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