71704-67-1

Usage

Molecular mass

168.15 g/mol The molecular mass of the compound is the sum of the atomic masses of all the atoms in the molecule, which in this case is 168.15 grams per mole.

Imidazole derivative

The compound is derived from imidazole, which is a heterocyclic aromatic organic compound with a five-membered ring structure containing four carbon atoms and one nitrogen atom.

Hydrazide functionality

The compound contains a hydrazide group (-NHNH2), which is a functional group consisting of two nitrogen atoms and two hydrogen atoms, known for its ability to form various chemical reactions and act as a reducing agent.

Potential uses

Organic synthesis and pharmaceutical research The compound has potential applications in the synthesis of various biologically active molecules, making it a valuable intermediate in the preparation of pharmaceuticals and other organic compounds.

Toxicity and reactivity

Handle with caution Due to its potential toxicity and reactivity, it is important to handle 1H-Imidazole-4-carboxylicacid,5-methyl-,hydrazide(9CI) with care and follow appropriate safety protocols.

Safety precautions

Well-ventilated area When working with 1H-Imidazole-4-carboxylic acid, 5-methyl-, hydrazide (9CI), it is important to work in a well-ventilated area to minimize the risk of exposure to harmful vapors or fumes.

Upstream product

• 51605-32-4 Ethyl 5-Methyl-4-imidazolecarboxylate 
• 64-17-5 ethanol 
• 29636-87-1 4⁽⁵⁾-methyl-5⁽⁴⁾-hydroxymethylimidazole 
• 78892-68-9 5-methyl-4-imidazole carboxylic acid methyl ester 
• 51605-32-4 ethyl 4⁽⁵⁾-methylimidazole-5⁽⁴⁾-carboxylate 

Downstream Products

• 308305-50-2 (isopropylidene)-5-methyl-imidazole-4-carbohydrazide 
• 349629-96-5 1-[(5-methyl-1H-imidazole-4-yl)carbonyl]-4-phenylthiosemicarbazide 
• 1246611-17-5 1-[(5-methyl-1H-imidazole-4-yl)carbonyl]-4-(4-chlorophenyl)thiosemicarbazide 
• 349630-19-9 1-[(5-methyl-1H-imidazole-4-yl)carbonyl]-4-(4-fluorophenyl)thiosemicarbazide 
• 1260230-25-8 4-cyclohexyl-5-(4-methylimidazol-5-yl)-s-triazole-3-thione 

Relevant academic research and scientific papers

Synthesis and evaluation of anti-Toxoplasma gondii and antimicrobial activities of thiosemicarbazides, 4-thiazolidinones and 1,3,4-thiadiazoles

In this work we reported the synthesis and evaluation of anti-Toxoplasma gondii and antimicrobial activities in vitro of three new compound series obtained from ethyl(5-methyl-1-H-imidazole-4-carboxylate): acylthiosemicarbazide analogues 3a-d, 4-thiazolidinone analogues 4a-d and 1,3,4-thiadiazole analogues 5a-d. All synthesized compounds were characterized by IR, 1H, 13C NMR and HRMS. The majority of the tested compounds show excellent anti-T. gondii activity when compared to hydroxyurea and sulfadiazine. In addition it was also shown that most of the compounds in this study have a better performance against intracellular tachyzoites. The results for antimicrobial activity evaluation showed weak antibacterial and antifungal activities for all the tested molecules, when compared with the standard drugs (chloramphenicol and rifampicin for antibacterial activity; nistatin and ketoconazole for antifungal activity).

Self-assembled polymetallic square grids ([2 × 2] M4, [3 × 3] M9) and trigonal bipyramidal clusters (M5) - Structural and magnetic properties

New self-assembled grids and clusters are reported, with square [2 × 2] M4 (M = Mn(ii)4, Cu(ii)4), trigonal-bipyramidal Mn(ii)5, and square [3 × 3] M9 (M = Mn(ii), Cu(ii)) examples. These are based on a series of ditopic and tritopic hydrazone ligands involving pyridine, pyrimidine and imidazole end groups. In all cases the metal centres are bridged by hydrazone oxygen atoms with large (>125°) bridge angles, leading to antiferromagnetic exchange for all the Mn systems (J = -2 to -5 cm-1), which results in S = 0 (Mn4), and S = 5/2 (Mn5, Mn9) ground states. The copper systems have a 90° alternation of the Jahn-Teller axes within the Cu4 and Cu8 grid rings (Cu9), which leads to magnetic orbital orthogonality, and dominant ferromagnetic coupling. For the Cu9 grid antiferromagnetic exchange between the ring and the central copper leads to a S = 7/2 ground state, while for the Cu4 grids S = 4/2 ground states are observed. The magnetic data have been treated using isotropic exchange models in the cases of the Cu4 and Cu9 grids, and the Mn5 clusters. However due to the enormity of a fully isotropic calculation a simplified model is used for the Mn9 grid, in which the outer Mn8 ring is treated as the equivalent of an isolated magnetic chain, with no coupling to the central metal ion. The Royal Society of Chemistry 2006.

Design and synthesis of novel potent antinociceptive agents: Methyl-imidazolyl N-acylhydrazone derivatives

This paper describes recent results of design, synthesis and pharmacological evaluation of new N-heterocyclic functionalized N-acylhydrazone compounds, belonging to the 2-methyl-imidazolyl-3-acylhydrazone class (4a-e). These compounds were planned by applying the molecular simplification strategy to propose the structural modifications on the previously described functionalized imidazo[1,2-a]pyridine 3-acylhydrazone series (2), which presented an important analgesic profile. This new series (4) was synthesized in order to investigate the possible pharmacophoric contribution of the N-heteroaromatic ring and N-acylhydrazone moieties to the analgesic activity. Compounds 4a-b are the most potent antinociceptive agents from this series. Copyright (C) 2000 Elsevier Science Ltd.

Triazine derivative, chymase activity inhibitor and nitric oxide production inhibitor

The present invention provides novel triazine derivatives which inhibit chymase activity and nitric oxide production. The triazine derivatives are useful for the prevention and treatment of bronchial asthma, allergic rhinitis and hives by inhibiting chyma

Method of treating hypertension using substituted imidazo[1,5-d]1,2,4-triazin-1(2H)-ones

This disclosure describes compositions of matter containing certain substituted imidazo[1,5-d]-1,2,4-triazin-1(2H)-ones and the method of treating hypertension therewith.