717127-76-9

Upstream product

• 55857-35-7 (E)-N-(2-aminobenzylidene)-4-methylaniline 
• 1026642-81-8 2-[(E)-3-(4-Methoxy-benzyloxymethyl)-pent-2-enyl]-3-oxo-pyrrolidine-1-carboxylic acid benzyl ester 
• 717127-64-5 5-[(E)-3-(4-Methoxy-benzyloxymethyl)-pent-2-enyl]-4-oxo-pyrrolidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester 
• 717127-61-2 (E)-2-Benzyloxycarbonylamino-5-(4-methoxy-benzyloxymethyl)-hept-4-enoic acid methyl ester 
• 717127-57-6 (E)-5-Acetoxymethyl-2-benzyloxycarbonylamino-hept-4-enoic acid methyl ester 
• 717127-98-5 (E)-2-Benzyloxycarbonylamino-5-hydroxymethyl-hept-4-enoic acid methyl ester 
• 717127-53-2 (E)-5-Acetoxymethyl-2-amino-hept-4-enoic acid methyl ester 
• 65305-57-9 Acetic acid (E)-4-chloro-2-ethyl-but-2-enyl ester 

Downstream Products

• 717127-40-7 3-(3-hydroxymethyl-pent-2-enyl)-1,3-dihydro-pyrrolo[3,4-b]quinoline-2-carboxylic acid benzyl ester 
• 717127-81-6 3-[2-(1-ethoxycarbonyl-ethyl)-3-ethyl-but-3-enyl]-1,3-dihydro-pyrrolo[3,4-b]quinoline-2-carboxylic acid benzyl ester 
• 55854-89-2 8-methyl-7-propionylindolizino[1,2-b]quinoline-9(11H)-one 

Relevant academic research and scientific papers

Total synthesis of nothapodytine B and (±)-mappicine

A novel, efficient total synthesis of the naturally occurring antiviral nothapodytine B (2, mappicine ketone) is reported. The approach is based on the successful implementation of the Johnson orthoester rearrangement of allylic alcohol 7 for assembly of a pyridone D ring precursor with the necessary functionalities. Nothapodytine B is converted into mappicine by NaBH4 reduction.