717129-75-4Relevant academic research and scientific papers
Highly enantioselective hydrogenation of 3,5-diketo esters: A formal synthesis of tetrahydrolipstatin
Polkowska, Jolanta,?ukaszewicz, Ewa,Kiegiel, Jaros?aw,Jurczak, Janusz
, p. 3873 - 3875 (2004)
Compound 4, obtained via a sequence of two consecutive alkylations of methyl 3,5-dioxohexanoate (5), was transformed into the enantiomerically pure lactone (3S,4S,6R)-2 being the precursor of tetrahydrolipstatin (1). The reaction sequence involves asymmetric catalytic hydrogenation of 4 as a crucial step.
