71731-75-4

Upstream product

• 73-34-7 6-deoxy-L-galactose 
• 71731-74-3 (2R,3S,4R,5S,6S)-2-(benzyloxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol 
• 77-76-9 2,2-dimethoxy-propane 
• 100-51-6 benzyl alcohol 
• 176776-17-3 benzyl L-fucopyranoside 

Downstream Products

• 858129-82-5 benzyl 2-O-(4-methoxybenzyl)-α-L-fucopyranoside 
• 858129-81-4 benzyl 3,4-O-isopropylidene-2-O-(4-methoxybenzyl)-α-L-fucopyranoside 
• 208467-65-6 benzyl 3,4-di-O-acetyl-2-azido-2-deoxy-α-L-fucopyranosyl-(1-2)-3,4-O-isopropylidene-α-L-fucopyranoside 

Relevant academic research and scientific papers

An efficient and scalable synthesis of 2,4-di-N-acetyl-l-altrose (l-2,4-Alt-diNAc)

Bacterial nonulosonic acids such as pseudaminic acids and others constitute a family of 9-carbon monosaccharides that contain a common 3-deoxy-2-ketoacid fragment but differ in their stereochemistries at 5 stereogenic centers between C-4 to C-8. Their unique structures make them attractive targets for use as antigens in vaccinations to combat drug-resistant bacterial infections and their challenging stereochemistries have attracted considerable attention from chemists. In this work we report the development of an improved synthesis for 2,4-di-N-acetyl-l-altrose (l-2,4-Alt-diNAc), which is a key hexose required for the chemical and chemoenzymatic synthesis of pseudaminic acids. Usingl-fucose as a starting material, our synthesis overcomes several pitfalls in previously reported syntheses.