7175-35-1Relevant academic research and scientific papers
Discovery of SMP-304, a novel benzylpiperidine derivative with serotonin transporter inhibitory activity and 5-HT1Aweak partial agonistic activity showing the antidepressant-like effect
Yoshinaga, Hidefumi,Masumoto, Shuji,Koyama, Koji,Kinomura, Naoya,Matsumoto, Yuji,Kato, Taro,Baba, Satoko,Matsumoto, Kenji,Horisawa, Tomoko,Oki, Hitomi,Yabuuchi, Kazuki,Kodo, Toru
, p. 293 - 304 (2016/12/22)
We report the discovery of a novel benzylpiperidine derivative with serotonin transporter (SERT) inhibitory activity and 5-HT1Areceptor weak partial agonistic activity showing the antidepressant-like effect. The 3-methoxyphenyl group and the ph
Stereoselective synthesis of enantiopure analogues of (-)-cephalotaxine
Berhal, Farouk,Perard-Viret, Joelle,Royer, Jacques
scheme or table, p. 325 - 332 (2010/06/12)
The asymmetric total synthesis of three analogues of (-)-cephalotaxine with structural modification of the aromatic ring was achieved in 16 steps and acceptable overall yields. The procedure used was quite similar to that reported by our group for the tot
Melanocortin receptor ligands
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Page/Page column 24, (2010/11/08)
Disclosed are MC-4 and/or MC-3 receptor ligands, the ligands having a structure according to Formula (I): wherein R2, R4, R4′, R5, R6, R6′, R7, R8, R8′, R9, R9′, R10, Ar, Z1, Z2, Z3, X, B, D, p, q, r and s are as described in the specification and claims, and optical isomers, diastereomers or enantiomers thereof; pharmaceutically-acceptable salts, hydrates, and biohydrolyzable esters, amides or imides thereof. Also disclosed are pharmaceutical compositions comprising the ligands of Formula (I), as well as methods of treating diseases mediate by the MC-4/MC-3 receptors, as described in the Detailed Descriptions section of the specification.
Pyridyl- and/or pyridoyl-(piperid-4-yl) ureas and analogues thereof
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, (2008/06/13)
The invention concerns the preparation of compounds of formula STR1 and acid addition and quaternary ammonium salts thereof, wherein the dotted line represents an optional bond, Ar represents a ring system of formula STR2 in which Q is O, S, --CR7/s
Piperid-4-yl ureas and thio ureas used as antidepressant agents
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, (2008/06/13)
The invention concerns the preparation of compounds of formula STR1 and acid addition and quaternary ammoniun salts thereof, wherein the dotted line represents an optional bond, Ar represents a ring system of formula STR2 in which Q is O, S, --CR7/s
