71750-15-7

Upstream product

• 71750-16-8 1-(Cyanmethyl)-1-hydroxy-4-tert.-butylcyclohexan 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 98-54-4 para-tert-butylphenol 
• 372-09-8 cyanoacetic acid 

Downstream Products

• 706813-21-0 (1-amino-4-tert-butyl-cyclohexyl)-acetonitrile 
• 706813-30-1 3-{4-[9-tert-butyl-2-oxo-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[5.5]undec-1-ylmethyl]-benzoylamino}-propionic acid tert-butyl ester 
• 706813-29-8 3-{4-[9-tert-butyl-2,4-dioxo-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[5.5]undec-1-ylmethyl]-benzoylamino}-propionic acid tert-butyl ester 
• 56300-88-0 2-(4-tert-butylcyclohexylidene)acetaldehyde 
• 706813-24-3 4-[9-tert-butyl-2,4-dioxo-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[5.5]undec-1-ylmethyl]-benzoic acid tert-butyl ester 
• 706813-27-6 4-[9-tert-butyl-2-oxo-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[5.5]undec-1-ylmethyl]-benzoic acid tert-butyl ester 
• 706813-25-4 4-[9-tert-butyl-2,4-dioxo-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[5.5]undec-1-ylmethyl]-benzoic acid 
• 706813-28-7 4-[9-tert-butyl-2-oxo-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[5.5]undec-1-ylmethyl]-benzoic acid 
• 706813-22-1 9-tert-butyl-4-imino-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[5.5]undecan-2-one 
• 706813-23-2 9-tert-butyl-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[5.5]undecane-2,4-dione 
• 706813-26-5 9-tert-butyl-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[5.5]undecan-2-one 

Relevant academic research and scientific papers

A method of preparing P-tert-butyl benzyl cyanide

The invention discloses a method for preparing butylphenylacetonitrile, and the method is capable of preparing butylphenylacetonitrile by using p-tert-butylphenol as a raw material through catalyzing, hydrogenating, and condensation with Knoevenagel of cyanoacetic acid, and catalyzing dehydro-aromatization, wherein a small amount of ethylbenzene is added into the reaction mixture in the dehydro-aromatization catalyzing step, and meanwhile, as the technical means of introducing inert gas with a certain flow rate is adopted, the preparation method provided by the invention has industrial application value. Compared with the existing preparation method, the method provided by the invention has the advantages that the raw material is easy to get, the yield is high, the cost is low, isomers which are difficult to separate are not contained, highly toxic sodium cyanide and other highly toxic irritating ingredients are not used, the three wastes are less, the security is high and the like, so that the method provided by the invention is suitable for industrial production.

Deracemization of axially chiral α,β-unsaturated aldehydes through an amino-catalyzed symmetry-making-symmetry-breaking cascade

Highly enantioenriched products have been prepared in good yields from racemic enal starting materials through a new deracemization strategy that employs an enantioconvergent amino-catalyzed symmetry-making-symmetry-breaking cascade. The reaction design features the tandem domination of product development and catalyst control in two reaction steps (see scheme).

Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists

A novel class of spiro-ureas has been discovered as potent human glucagon receptor antagonists in both binding and functional assays. Preliminary studies have revealed that compound 15 is an orally active human glucagon receptor antagonist in a transgenic