71764-61-9

Upstream product

• 554-95-0 benzene-1,3,5-tricarboxylic acid 
• 587-14-4 N,N'-diphenylsulfamide 
• 4422-95-1 1,3,5-benzene tris(carbonyl chloride) 
• 62-53-3 aniline 

Downstream Products

• 117070-36-7 N,N',N-trimethyl-N,N',N-triphenyl-1,3,5-benzenetricarboxamide 

Relevant academic research and scientific papers

General method for quickly synthesizing bridge-linked bisamide, triamide and tetraamide derivatives through ultrasonic radiation method and application

The invention belongs to the technical field of organic synthesis, specifically discloses bridge-linked bisamide, triamide and tetraamide derivatives and a general method for ultrasonic radiation quick synthesis thereof, and also relates to the applicatio

Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum

Quinoline antimalarials target hemozoin formation causing a cytotoxic accumulation of ferriprotoporphyrin IX (Fe(III)PPIX). Well-developed SAR models exist for β-hematin inhibition, parasite activity, and cellular mechanisms for this compound class, but no comparably detailed investigations exist for other hemozoin inhibiting chemotypes. Here, benzamide analogues based on previous HTS hits have been purchased or synthesized. Only derivatives containing an electron deficient aromatic ring and capable of adopting flat conformations, optimal for π-π interactions with Fe(III)PPIX, inhibited β-hematin formation. The two most potent analogues showed nanomolar parasite activity, with little CQ cross-resistance, low cytotoxicity, and high in vitro microsomal stability. Selected analogues inhibited hemozoin formation in Plasmodium falciparum causing high levels of free heme. In contrast to quinolines, introduction of amine side chains did not lead to benzamide accumulation in the parasite. These data reveal complex relationships between heme binding, free heme levels, cellular accumulation, and in vitro activity of potential novel antimalarials.

Insights into the formation of chiral second sphere coordination complexes with aromatic tris amines: combined single crystal X-ray crystallography and molecular modeling analyses

A family of isostructural, chiral supramolecular networks have been obtained in the solid state by exploiting second sphere coordination interactions in the self-assembly of achiral tris amines L1 and L2 with tetrahalometallate and halide ions. Quantum-Mechanical (QM) calculations specific for solid phases provided additional insights into the intramolecular and packing interactions which determine chirality, pointing to a direct effect of the methyl groups of the central benzene ring.

TRICYCLIC AMINO CONTAINING COMPOUNDS FOR TREATMENT OR PREVENTION OF SYMPTOMS ASSOCIATED WITH ENDOCRINE DYSFUNCTION

The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.

Discovery of small molecule CXCR4 antagonists

In light of a proposed molecular mechanism for the C-X-C chemokine receptor type 4 (CXCR4) antagonist 1 (AMD3100), a template with the general structure 2 was designed, and 15 was identified as a lead by means of an affinity binding assay against the liga

CXCR4 ANTAGONISTS FOR THE TREATMENT OF HIV INFECTION

The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor, and in particular to inhibit viral entry of certain viruses. Certain compounds in particular can reduce entry of immunodeficiency virus (HIV) into a cell while not reducing the capacity of stem cells to proliferate, and therefore can be useful for long term treatment regimes. The compounds are useful in particular in the treatment or prevention of HIV infections.

Structures and excited states of extended and folded mono-, di-, and tri-N-arylbenzamides

The relationship between molecular structure and electronic properties of 18 N-arylbenzamides has been investigated. The secondary amides adopt extended trans-amide conformations, whereas the tertiary amides adopt folded cis-amide conformations in which the N-aryl group is approximately perpendicular to the benzoyl group. The N-aryl groups of the tertiary di- and triamides occupy the same face of the benzoyl group and display edge-to-face aryl-aryl interactions. The long-wavelength absorption maxima of the secondary amides are red-shifted as the number of N-aryl groups increases, whereas the tertiary amides display are blue-shifted. ZINDO calculations aid in the assignment of the absorption and luminescence spectra. In all cases the lowest energy singlet state is assigned to a forbidden n,B* (carbonyl lone-pair to benzoyl) transition. The structureless fluorescence of the secondary and tertiary amides is assigned to planar and twisted n.B* singlets, respectively. The allowed absorption bands are assigned to A,B* (arene-to-benzoyl) or A,A* (arene-to-arene) transitions which are localized on a single arene, and the structured phosphorescence is assigned to A,A* triplet states.

Extended-core discotic liquid crystals based on the lntramolecular H-bonding in N-acylated 2,2'-bipyridine-3,3'-diamine moieties

A new type of disc-shaped molecule (1a-c) has been synthesised and characterised. The molecules were built up by linking three lipophilic, N-monoacylated 2,2'-bipyridine-3,3'-diamine wedges to a central 1,3,5-benzenetricarbonyl unit. They show liquid crys