717841-92-4Relevant academic research and scientific papers
One-pot synthesis of 1,6-naphthyridines, pyranopyridines and thiopyranopyridines
Abdel-Wadood, Fatma K.,Abdel-Monem, Maisa I.,Fahmy, Atiat M.,Geies, Ahmed A.
experimental part, p. 303 - 312 (2009/01/31)
A one-step synthesis of [1,6]naphthyridine-2(1H)-thione (3a), pyrano[3,4-b]pyridine-2(1H)-thione (3b), thiopyrano[3,4-b]pyridine-2(1H)-thione (3c) and 6-oxoquinoline-2(1H)-thione (3d) through the reaction of benzylidene-cyanothioacetamide (1) with cyclic ketones 2a-d is described. The reaction of 3a-d with organyl chlorides yielded the 2-alkylthio-3-cyanopyridines 4a-p which upon refluxing in ethanolic sodium ethoxide afforded the thieno[2,3-b]pyridine derivatives 5a-n. Some of the synthesized compounds were screened for the activity against bacteria and fungi.
