71785-97-2Relevant articles and documents
Total synthesis of (+)-varitriol
Palik, Miroslav,Karlubikova, OL'Ga,Lasikova, Angelika,Kozisek, Jozef,Gracza, Tibor
body text, p. 709 - 715 (2009/07/19)
The total synthesis of natural (+)-varitriol (1) was accomplished by starting from dimethyl L-tartrate. The key features were a substrate selective and diastereoselective PdII-catalysed bicyclisation of unsaturated protected triol 9 followed by regioselective ring-opening of bicyclic skeleton 10. The absolute configuration of the target was confirmed by single-crystal X-ray analysis for the first time.
