717871-75-5 Usage
Molecular Weight
144.55 g/mol
Structure
A pyrazole ring with a carbonyl chloride group attached to the 3-position and a chlorine atom attached to the 4-position.
Purity
Typically >95% pure
Physical State
Solid
Color
Off-white to pale yellow
Melting Point
72-74°C
Boiling Point
Not applicable as it is a solid
Solubility
Soluble in common organic solvents such as dichloromethane, ethyl acetate, and acetone.
Reactivity
Highly reactive towards nucleophiles due to the presence of the carbonyl chloride group.
Applications
Used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Commonly used in the production of biologically active compounds.
Safety
Handle with care as it may be harmful if inhaled, ingested, or absorbed through the skin. Wear appropriate personal protective equipment when handling.
Check Digit Verification of cas no
The CAS Registry Mumber 717871-75-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,1,7,8,7 and 1 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 717871-75:
(8*7)+(7*1)+(6*7)+(5*8)+(4*7)+(3*1)+(2*7)+(1*5)=195
195 % 10 = 5
So 717871-75-5 is a valid CAS Registry Number.
717871-75-5Relevant articles and documents
Structure-Activity Relationship for the Oxadiazole Class of Antibacterials
Boudreau, Marc A.,Ding, Derong,Meisel, Jayda E.,Janardhanan, Jeshina,Spink, Edward,Peng, Zhihong,Qian, Yuanyuan,Yamaguchi, Takao,Testero, Sebastian A.,O'Daniel, Peter I.,Leemans, Erika,Lastochkin, Elena,Song, Wei,Schroeder, Valerie A.,Wolter, William R.,Suckow, Mark A.,Mobashery, Shahriar,Chang, Mayland
, p. 322 - 326 (2020)
A structure-activity relationship (SAR) for the oxadiazole class of antibacterials was evaluated by syntheses of 72 analogs and determination of the minimal-inhibitory concentrations (MICs) against the ESKAPE panel of bacteria. Selected compounds were further evaluated for in vitro toxicity, plasma protein binding, pharmacokinetics (PK), and a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) infection. Oxadiazole 72c shows potent in vitro antibacterial activity, exhibits low clearance, a high volume of distribution, and 41% oral bioavailability, and shows efficacy in mouse models of MRSA infection.
