71815-36-6Relevant academic research and scientific papers
New Flavoid Glycosides of Helicteres Angustifolia
Chen, Zong-Tsi,Lee, Shwu-Woan,Chen, Chiu-Ming
, p. 1399 - 1406 (1994)
Two new flavonoid glycosides, takakin 8-O-β-D-glucuronide 6''-methyl ester (2), takakin 8-O-β-D-glucuronide 2''-sodium sulfonate (3) together with a known flavonoid glycoside, takakin 8-O-β-D-glucuronide were isolated from the root bark of Helicteres angustifolia (Sterculiaceae).The structures of these compounds were established on the basis of spectroscopic and chemical evidence.
Phytochemical Characterization of Low Molecular Weight Constituents from Marshmallow Roots (Althaea officinalis) and Inhibiting Effects of the Aqueous Extract on Human Hyaluronidase-1
Sendker, Jandirk,B?ker, Ines,Lengers, Isabelle,Brandt, Simone,Jose, Joachim,Stark, Timo,Hofmann, Thomas,Fink, Careen,Abdel-Aziz, Heba,Hensel, Andreas
, p. 290 - 297 (2017/03/09)
Extract RE was obtained from the roots of Althaea officinalis in a yield of 8.1%, related to the dried plant material, by extraction with MeOH-H2O (1:1), followed by precipitation with EtOH to remove high molecular weight constituents. Phytochemical investigation of RE revealed the presence of N-phenylpropenoyl-l-amino acid amides 1-5, 8% glycine betaine 6, about 9% total amino acids with proline as the main compound, and about 61% mono- and oligomeric carbohydrates with sucrose as the main compound. Further fractionation revealed the presence of a hypolaetin diglycoside (12) and four hypolaetin glycosides (7-9 and 11) with O-sulfocarbohydrate moieties; additionally, 4′-O-methylisoscutellarein-8-O-β-d-(3-O-sulfo)glucuronopyranoside (10) and the diglycosylated coumarin haploperoside D (13) were identified. The hypolaetin-O-sulfoglycosides 7-10 are new natural products. RE inhibited the enzymatic activity of surface-displayed human hyaluronidase-1 on Escherichia coli F470 cells with an IC50 of 7.7 mg/mL. RE downregulated mRNA expression of hyal-1 in HaCaT keratinocytes at 125 and 250 μg/mL, respectively. These data contribute to a deeper phytochemical understanding of marshmallow root extracts and to the positive influence of extracts used for therapy of irritated and inflamed buccal tissue and cough.
