7182-48-1Relevant academic research and scientific papers
An efficient one-pot synthesis of pyrrolines and tetrahydropyridines from their chloro-precursors via in situ aza-Wittig reaction
Singh, Pradeep N.D.,Klima, Rodney F.,Muthukrishnan, Sivaramakrishnan,Murthy, Rajesh S.,Sankaranarayanan, Jagadis,Stahlecker, Heidi M.,Patel, Bhavika,Gudmundsdóttir, Anna D.
, p. 4213 - 4217 (2005)
A simple and efficient method for synthesizing pyrrolines and tetrahydropyridines via an intramolecular aza-Wittig reaction has been achieved by microwave irradiation of the corresponding chloro-alkane derivatives in the presence of tertiary phosphite and sodium azide. The in situ formation of the alkyl azides makes this a facile and safe method for aza-Wittig reactions.
