718599-83-8Relevant academic research and scientific papers
Synthesis and characterization of ruthenium(II) complexes with the new ligand 2-phenylazopyridine-5-sulfonic acid (Hsazpy): In search for new anticancer agents
Hotze, Anna C. G.,Kooijman, Huub,Spek, Anthony L.,Haasnoot, Jaap G.,Reedijk, Jan
, p. 565 - 569 (2004)
Isomers of dichlorobis(2-phenylazopyridine)ruthenium(II) [Ru(azpy) 2Cl2], especially the so-called α isomer, display remarkably high cytotoxicities against human tumor cell lines. Unfortunately, the parent [Ru(azpy)2Cl2] compounds are poorly water-soluble. In this paper the synthesis and characterization of the new water-soluble ligand 2-phenylazopyridine-5-sulfonic acid (Hsazpy) is described. Use of this ligand in reaction with RuCl3 gave two isomers, which were isolated as α- and β-[NEt4]2[Ru(sazpy) 2Cl2]. The compounds have been fully characterized by (2D) NMR spectroscopy. The molecular structure of the α isomer of [NEt 4]2[Ru(sazpy)2Cl2]·2H 2O has been determined by single-crystal structure analysis. The packing in the crystal structure of α-[NEt4] 2[Ru(sazpy)2Cl2]·2H2O shows an interesting hydrogen-bonding pattern in which two water molecules are involved. One water molecule bridges between a Cl ligand and a SO 3- group within one ruthenium moiety, the other water molecule forms a bridge between two SO3- groups from two different ruthenium centers, resulting in a chain-like structure. Preliminary evaluation of the cytotoxicity by means of the IC50 value in A2780 cell line classifies α-[NEt4]2[Ru(sazpy) 2Cl2] as non-toxic, but this does not rule out other anticancer activities.
