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SN-38-D3 is a deuterated analogue of SN-38 (S589950), which is a metabolite of Irinotecan, a potent DNA topoisomerase inhibitor. It is commonly used in cancer research and therapeutic applications due to its ability to target and inhibit the activity of DNA topoisomerase enzymes, leading to the prevention of DNA replication and transcription in cancer cells.

718612-49-8

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718612-49-8 Usage

Uses

Used in Cancer Research:
SN-38-D3 is used as a research tool for studying the mechanisms of action and the effectiveness of DNA topoisomerase inhibitors in cancer treatment. Its deuterated nature allows for the investigation of the stability, metabolism, and pharmacokinetics of the compound in various experimental settings.
Used in Cancer Therapy:
SN-38-D3 is used as a potential therapeutic agent for the treatment of various types of cancer. Its ability to inhibit DNA topoisomerase enzymes can lead to the suppression of tumor growth and the induction of apoptosis in cancer cells.
Used in Drug Development:
SN-38-D3 is used in the development of new anticancer drugs and drug delivery systems. Its deuterated form can provide insights into the optimization of drug design, formulation, and targeting strategies to improve the efficacy and safety of cancer treatments.
Used in Pharmaceutical Industry:
SN-38-D3 is used as a reference compound for the quality control and standardization of Irinotecan and its metabolites in pharmaceutical formulations. This ensures the consistency, potency, and safety of cancer therapeutics for patients.
Used in Biochemical Assays:
SN-38-D3 is used as a labeled substrate or inhibitor in biochemical assays to study the activity and regulation of DNA topoisomerase enzymes. This can help in understanding the molecular mechanisms underlying the action of topoisomerase inhibitors and their potential as therapeutic targets in cancer.

Check Digit Verification of cas no

The CAS Registry Mumber 718612-49-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,1,8,6,1 and 2 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 718612-49:
(8*7)+(7*1)+(6*8)+(5*6)+(4*1)+(3*2)+(2*4)+(1*9)=168
168 % 10 = 8
So 718612-49-8 is a valid CAS Registry Number.

718612-49-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name SN-38-d3

1.2 Other means of identification

Product number -
Other names SN 38-d3 Lactone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:718612-49-8 SDS

718612-49-8Upstream product

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