718614-05-2

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 718613-98-0 C₂₀H₃₃NO₄Si 
• 114817-96-8 (4S,5R)-2,2-dimethyl-4-hydroxymethyl-5-vinyl-1,3-dioxolane 
• 213767-09-0 2,3-O-isopropylidene-L-erythrofuranose 
• 718613-99-1 (3R,4R,5S)-2-Benzyl-3-[(4R,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-5-((3aR,5S,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-isoxazolidine-4-carboxylic acid methyl ester 

Downstream Products

• 718614-00-7 Acetic acid (3R,4S,5S)-2-benzyl-3-[(4R,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-5-((3aR,5S,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-isoxazolidin-4-ylmethyl ester 

Relevant academic research and scientific papers

Synthesis of a branched chain aza-C-disaccharide via the cycloaddition of a chiral nitrone to an alkene, both sugar derivatives

A multistep synthesis of a protected aza-C-disaccharide derivative with a pyrrolidine ring as the azasugar component is described. The key step is a stereoselective cycloaddition reaction of a chiral nitrone derived from D-ribose and a sugar alkene derived from D-galactose. An intramolecular N-alkylation followed by a reductive cleavage of the isoxazolidine N-O bond, in one pot, gave the final product.