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N-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-yl}-N',N'-diethyl-propane-1,3-diamine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

718617-99-3

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718617-99-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 718617-99-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,1,8,6,1 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 718617-99:
(8*7)+(7*1)+(6*8)+(5*6)+(4*1)+(3*7)+(2*9)+(1*9)=193
193 % 10 = 3
So 718617-99-3 is a valid CAS Registry Number.

718617-99-3Downstream Products

718617-99-3Relevant articles and documents

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

Warmus, Joseph S.,Flamme, Cathlin,Zhang, Lu Yan,Barrett, Stephen,Bridges, Alexander,Chen, Huifen,Gowan, Richard,Kaufman, Michael,Sebolt-Leopold, Judy,Leopold, Wilbur,Merriman, Ronald,Ohren, Jeffrey,Pavlovsky, Alexander,Przybranowski, Sally,Tecle, Haile,Valik, Heather,Whitehead, Christopher,Zhang, Erli

scheme or table, p. 6171 - 6174 (2009/07/18)

This paper reports a second generation MEK inhibitor. The previously reported potent and efficacious MEK inhibitor, PD-184352 (CI-1040), contains an integral hydroxamate moiety. This compound suffered from less than ideal solubility and metabolic stabilit

MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL PHENYLAMINE DERIVATES

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Page 20 - 21, (2010/02/07)

This invention provides substituted Phenyl-(2-[1,3,4]thiadiazol-2-yl-phenyl)-amine and (2-[1,3,4]Oxadiazol-2-yl-phenyl)phenyl-amine compounds which act as inhibitors of MAPKIERK Kinase ("MEK") enzymes and pharmaceutical compositions and methods for their use in immunomodulation and in the treatment and alleviation of inflammation, and proliferative diseases such as cancer and restenosis.

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