718617-99-3Relevant articles and documents
2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)
Warmus, Joseph S.,Flamme, Cathlin,Zhang, Lu Yan,Barrett, Stephen,Bridges, Alexander,Chen, Huifen,Gowan, Richard,Kaufman, Michael,Sebolt-Leopold, Judy,Leopold, Wilbur,Merriman, Ronald,Ohren, Jeffrey,Pavlovsky, Alexander,Przybranowski, Sally,Tecle, Haile,Valik, Heather,Whitehead, Christopher,Zhang, Erli
scheme or table, p. 6171 - 6174 (2009/07/18)
This paper reports a second generation MEK inhibitor. The previously reported potent and efficacious MEK inhibitor, PD-184352 (CI-1040), contains an integral hydroxamate moiety. This compound suffered from less than ideal solubility and metabolic stabilit
MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL PHENYLAMINE DERIVATES
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Page 20 - 21, (2010/02/07)
This invention provides substituted Phenyl-(2-[1,3,4]thiadiazol-2-yl-phenyl)-amine and (2-[1,3,4]Oxadiazol-2-yl-phenyl)phenyl-amine compounds which act as inhibitors of MAPKIERK Kinase ("MEK") enzymes and pharmaceutical compositions and methods for their use in immunomodulation and in the treatment and alleviation of inflammation, and proliferative diseases such as cancer and restenosis.