718632-79-2

Upstream product

• 4005-49-6 N-benzoyladenine 
• 718632-77-0 (2R,4S)-2-azidomethyl-4-(p-toluenesulfonyl)oxy-N-(tert-butoxycarbonylmethyl)pyrrolidine 
• 718632-72-5 2-azidomethyl-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 114676-60-7 (2R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-methanesulfonyloxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 114676-58-3 (2R,4R)-tert-butyl 4-((tert-butyldimethylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 718632-75-8 (2R,4S)-2-azidomethyl-4-formyloxy-N-(tert-butoxycarbonylmethyl)-pyrrolidine 
• 718632-76-9 (2R,4S)-2-azidomethyl-4-hydroxy-N-(tert-butoxycarbonylmethyl)-pyrrolidine 

Downstream Products

• 718632-80-5 (2'R,4'R)-2'-[(fluoren-9-yl-methoxycarbonyl)aminomethyl]-4'-(N⁶-benzoyladenin-9-yl)-N₁'-(tert-butoxycarbonylmethyl)-pyrrolidine 
• 927198-64-9 (2'R,4'R)-2'-aminomethyl-4'-(N⁶-benzoyladenin-9-yl)-N₁'-(tert-butoxycarbonylmethyl)-pyrrolidine 

Relevant academic research and scientific papers

Homopolymeric pyrrolidine-amide oligonucleotide mimics: Fmoc-synthesis and DNA/RNA binding properties

By chemically modifying or replacing the backbone of oligonucleotides it is possible to modulate the DNA and RNA recognition properties and fine-tune the physiochemical properties of oligomers. This is important because it challenges our understanding of

Nucleic acid binding properties of thyminyl and adeninyl pyrrolidine-amide oligonucleotide mimics (POM).

Adeninyl POM was prepared using solid-phase peptide chemistry and shown to exhibit higher affinity for complementary DNA and RNA than the corresponding adeninyl PNA.